Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989949641> ?p ?o ?g. }
- W2989949641 abstract "Summary The neuronal protein complexin contains multiple domains that exert both clamping and facilitatory functions to tune spontaneous and action potential triggered synaptic release. We address the clamping mechanism and show that the accessory helix of complexin arrests the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex that forms the core machinery of intracellular membrane fusion. In a reconstituted fusion assay, site- and stage-specific photo-cross-linking reveals that prior to fusion the complexin accessory helix laterally binds the membrane-proximal C-terminal ends of SNAP25 and VAMP2. Corresponding complexin interface mutants selectively increase spontaneous release of neurotransmitter in living neurons, implying that the accessory helix suppresses final zippering/assembly of the SNARE four-helix bundle by restraining VAMP2 and SNAP25." @default.
- W2989949641 created "2019-12-05" @default.
- W2989949641 creator A5001571055 @default.
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- W2989949641 creator A5090859550 @default.
- W2989949641 date "2019-11-21" @default.
- W2989949641 modified "2023-10-01" @default.
- W2989949641 title "Complexin suppresses spontaneous exocytosis by capturing the membrane-proximal regions of VAMP2 and SNAP25" @default.
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