FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989955931> ?p ?o ?g. }

• W2989955931 endingPage "4384" @default.
• W2989955931 startingPage "4384" @default.
• W2989955931 abstract "This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC). DEN-induced rats and HepG2 cells based on the microfluidic chip were employed, while the mRNA and protein expression of microRNA-221, PI3K, p-Akt and PTEN were evaluated by RT-PCR and Western blot analysis. Based on Microfluidic Chip and DEN-induced rat model, OB effectively exerts anti-liver cancer effect both in vitro and in vivo, and the expression of miR-221 in OB treated groups was significantly lower than that in the control group (** p < 0.01). The RT-PCR and Western blot results suggested the PI3K mRNA and protein in OB treated groups were both lower than those in control group and indicated the overexpression of PTEN. Therefore, OB effectively exerts anticancer effects by positively regulating the PTEN gene and then inactivating the PI3K/Akt signaling pathway through down-regulating the expression of the microRNA-221, thereby inducing apoptosis of liver cancer cells. This study offers a theoretical evidence for further development and clinical guidance of OB as an anti-tumor agent." @default.
• W2989955931 created "2019-12-05" @default.
• W2989955931 creator A5001605502 @default.
• W2989955931 creator A5030088504 @default.
• W2989955931 creator A5063936933 @default.
• W2989955931 creator A5070235786 @default.
• W2989955931 creator A5074357549 @default.
• W2989955931 date "2019-11-30" @default.
• W2989955931 modified "2023-10-18" @default.
• W2989955931 title "Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer" @default.
• W2989955931 cites W1117348434 @default.
• W2989955931 cites W1581931615 @default.
• W2989955931 cites W1582495617 @default.
• W2989955931 cites W1817650983 @default.
• W2989955931 cites W1973577899 @default.
• W2989955931 cites W1978400685 @default.
• W2989955931 cites W1983734516 @default.
• W2989955931 cites W1990288360 @default.
• W2989955931 cites W2000230628 @default.
• W2989955931 cites W2017026391 @default.
• W2989955931 cites W2034402063 @default.
• W2989955931 cites W2040945369 @default.
• W2989955931 cites W2048466758 @default.
• W2989955931 cites W2050057869 @default.
• W2989955931 cites W2051808965 @default.
• W2989955931 cites W2054055335 @default.
• W2989955931 cites W2060459012 @default.
• W2989955931 cites W2073146012 @default.
• W2989955931 cites W2073391234 @default.
• W2989955931 cites W2088980666 @default.
• W2989955931 cites W2105639434 @default.
• W2989955931 cites W2124231599 @default.
• W2989955931 cites W2141089321 @default.
• W2989955931 cites W2141216640 @default.
• W2989955931 cites W2146043669 @default.
• W2989955931 cites W2160919000 @default.
• W2989955931 cites W2162224376 @default.
• W2989955931 cites W2163724251 @default.
• W2989955931 cites W2171348481 @default.
• W2989955931 cites W2345310808 @default.
• W2989955931 cites W2545725900 @default.
• W2989955931 cites W2583484614 @default.
• W2989955931 cites W2592297915 @default.
• W2989955931 cites W2618506127 @default.
• W2989955931 cites W2798086926 @default.
• W2989955931 cites W2805889788 @default.
• W2989955931 cites W3024106691 @default.
• W2989955931 cites W3025733170 @default.
• W2989955931 cites W414810430 @default.
• W2989955931 doi "https://doi.org/10.3390/molecules24234384" @default.
• W2989955931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6930563" @default.
• W2989955931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31801250" @default.
• W2989955931 hasPublicationYear "2019" @default.
• W2989955931 type Work @default.
• W2989955931 sameAs 2989955931 @default.
• W2989955931 citedByCount "15" @default.
• W2989955931 countsByYear W29899559312020 @default.
• W2989955931 countsByYear W29899559312021 @default.
• W2989955931 countsByYear W29899559312022 @default.
• W2989955931 countsByYear W29899559312023 @default.
• W2989955931 crossrefType "journal-article" @default.
• W2989955931 hasAuthorship W2989955931A5001605502 @default.
• W2989955931 hasAuthorship W2989955931A5030088504 @default.
• W2989955931 hasAuthorship W2989955931A5063936933 @default.
• W2989955931 hasAuthorship W2989955931A5070235786 @default.
• W2989955931 hasAuthorship W2989955931A5074357549 @default.
• W2989955931 hasBestOaLocation W29899559311 @default.
• W2989955931 hasConcept C104317684 @default.
• W2989955931 hasConcept C145059251 @default.
• W2989955931 hasConcept C153911025 @default.
• W2989955931 hasConcept C185592680 @default.
• W2989955931 hasConcept C190283241 @default.
• W2989955931 hasConcept C207001950 @default.
• W2989955931 hasConcept C2776231280 @default.
• W2989955931 hasConcept C2776415932 @default.
• W2989955931 hasConcept C2777609662 @default.
• W2989955931 hasConcept C2778019345 @default.
• W2989955931 hasConcept C502942594 @default.
• W2989955931 hasConcept C54355233 @default.
• W2989955931 hasConcept C55493867 @default.
• W2989955931 hasConcept C75217442 @default.
• W2989955931 hasConcept C86554907 @default.
• W2989955931 hasConcept C86803240 @default.
• W2989955931 hasConceptScore W2989955931C104317684 @default.
• W2989955931 hasConceptScore W2989955931C145059251 @default.
• W2989955931 hasConceptScore W2989955931C153911025 @default.
• W2989955931 hasConceptScore W2989955931C185592680 @default.
• W2989955931 hasConceptScore W2989955931C190283241 @default.
• W2989955931 hasConceptScore W2989955931C207001950 @default.
• W2989955931 hasConceptScore W2989955931C2776231280 @default.
• W2989955931 hasConceptScore W2989955931C2776415932 @default.
• W2989955931 hasConceptScore W2989955931C2777609662 @default.
• W2989955931 hasConceptScore W2989955931C2778019345 @default.
• W2989955931 hasConceptScore W2989955931C502942594 @default.
• W2989955931 hasConceptScore W2989955931C54355233 @default.
• W2989955931 hasConceptScore W2989955931C55493867 @default.
• W2989955931 hasConceptScore W2989955931C75217442 @default.
• W2989955931 hasConceptScore W2989955931C86554907 @default.

• next