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• W2989958619 abstract "Abstract Detection of host integrated viral oncogenes are critical for early and point-of-care molecular diagnostics of virus-induced carcinoma. However, available diagnostic approaches are incapable of combining both cost-efficient medical diagnosis and high analytical performances. To circumvent this, we have developed an improved IDE-based nanobiosensor for biorecognition of HPV-16 infected cervical cancer cells through electrochemical impedance spectroscopy. The system is fabricated by coating gold (Au) doped zinc oxide (ZnO) nanorods interfaced with HPV-16 viral DNA bioreceptors on top of the Interdigitated Electrode (IDE) chips surface. Due to the concurrently improved sensitivity and biocompatibility of the designed nanohybrid film, Au decorated ZnO-Nanorod biosensors demonstrate exceptional detection of HPV-16 E6 oncogene, the cancer biomarker for HPV infected cervical cancers. This sensor displayed high levels of sensitivity by detecting as low as 1fM of viral E6 gene target. The sensor also exhibited a stable functional life span of more than 5 weeks, good reproducibility and high discriminatory properties against HPV-16. Sensor current responses are obtained from cultured cervical cancer cells which are close to clinical cancer samples. Hence, the developed sensor is an adaptable tool with high potential for clinical diagnosis especially useful for economically challenged countries/regions." @default.
• W2989958619 created "2019-12-05" @default.
• W2989958619 creator A5010930789 @default.
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• W2989958619 creator A5064000573 @default.
• W2989958619 date "2019-11-19" @default.
• W2989958619 modified "2023-10-18" @default.
• W2989958619 title "Gold-Hybridized Zinc Oxide Nanorods as Real-Time Low-Cost NanoBiosensors for Detection of virulent DNA signature of HPV-16 in Cervical Carcinoma" @default.
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• W2989958619 doi "https://doi.org/10.1038/s41598-019-53476-9" @default.
• W2989958619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6864064" @default.
• W2989958619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31745139" @default.
• W2989958619 hasPublicationYear "2019" @default.
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