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- W2989973809 abstract "Surgical patients are getting older with increasing comorbidity. Acute kidney injury (AKI) is a commonly underesti- mated perioperative complication. 2-18% of hospitalized patients and 22-57% of patients in the intensive care unit develop AKI. Even though it has a major impact on patients' outcomes, it goes unrecognized in 57-75.6% of cases.This review is based on pertinent papers retrieved by a selective search in PubMed and the Cochrane Library employ- ing the searching terms acute kidney injury, biomarker, perioperative, renal function, and KDIGO.The pathophysiology of AKI is complex. Conventional biomarkers are either not specific enough (urine output) or not sensitive enough (serum creatinine) for timely diagnosis. In view of the pathophysiology of the condition and the limited treat- ment options for it, the early detection of subclinical AKI (kidney damage without functional impairment) would seem to be a reasonable first step toward the prevention of worsening or permanent renal injury. New biomarkers of damage enable the early initiation of nephroprotective interventions. According to the Kidney Disease: Improving Global Outcomes (KDIGO) statement, a multimodal treatment approach is needed, including, among other things, optimization of hemodynamics and the discontinu- ation of nephrotoxic drugs.It is essential to identify patients at risk and sensitize the treating personnel to the implementation of the guidelines. The incorporation of new biomarkers into routine clinical practice is also reasonable and necessary. Future clinical trials must show in what form these biomarkers should be used (singly or collectively)." @default.
- W2989973809 created "2019-12-05" @default.
- W2989973809 creator A5002129932 @default.
- W2989973809 creator A5019726220 @default.
- W2989973809 creator A5031471398 @default.
- W2989973809 creator A5055462266 @default.
- W2989973809 date "2019-12-06" @default.
- W2989973809 modified "2023-09-25" @default.
- W2989973809 title "Acute Kidney Injury" @default.
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