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• W2990004766 abstract "Abstract Diffusion-weighted steady-state free precession (DW-SSFP) is an SNR-efficient diffusion imaging method. The improved SNR and resolution available at ultra-high field has motivated its use at 7T. However, these data tend to have severe B 1 inhomogeneity, leading not only to spatially varying SNR, but also to spatially varying diffusivity estimates, confounding comparisons both between and within datasets. This study proposes the acquisition of DW-SSFP data at two-flip angles in combination with explicit modelling of non-Gaussian diffusion to address B 1 inhomogeneity at 7T. DW-SSFP datasets were acquired from five fixed whole human post-mortem brains with a pair of flip angles that jointly optimize the diffusion contrast-to-noise across the brain. We compared one and two flip-angle DW-SSFP data using a diffusion tensor model that incorporates the full DW-SSFP Buxton signal model. The two-flip angle data were subsequently fitted using a modified DW-SSFP signal model that incorporates a Gamma distribution of diffusivities. This allowed us to generate tensor maps at a single, SNR-optimal effective b-value yielding more consistent SNR across tissue, in addition to eliminating the B 1 dependence on diffusion coefficients and orientation maps. Our proposed approach will allow the use of DW-SSFP at 7T to derive diffusivity estimates that have greater interpretability, both within a single dataset and between experiments. Highlights B 1 inhomogeneity at 7T leads to spatially varying SNR & ADC estimates in DW-SSFP 2-flip angle DW-SSFP data can address B 1 effects in a cohort of post-mortem brains Our approach reduces degradations in PDD estimates & improves whole brain coverage Our approach provides a means to define ADCs at an SNR-optimal effective b-value" @default.
• W2990004766 created "2019-12-05" @default.
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• W2990004766 date "2019-12-02" @default.
• W2990004766 modified "2023-09-23" @default.
• W2990004766 title "Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP" @default.
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• W2990004766 doi "https://doi.org/10.1101/861880" @default.
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