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- W2990018548 abstract "Introduction. Magnesium is directly involved in the thyroid gland function. However, the data about the thyroid gland histomorphological changes after magnesium ions influence are often ambiguous. This may be due to the use of the various magnesium sources of in experiments, differences in the magnesium-containing compounds dosage of, animals ages, seasonality and duration of the experiments. The aim of the study was to investigate the morphological changes in the thyroid of young rats after the magnesium chloride ingestion.Materials and methods. The experiments were performed on 24 Wistar male rats of 3 months of age. Animals of the experimental group, in addition to the standard diet, received magnesium chloride daily for 21 days at a dose of 50 mg/kg of body weight. Histological slides were made from the thyroid tissue according to the standard method. The gland morphometry was performed on digital images using the computer program Image J. The magnesium cations level in the serum and suspension of red blood cells was determined. .Results. The data indicate that the 21 daily magnesium chloride ingestion in rats leads to a decrease in cross-sectional area of thyroid follicles and colloid, to the increase of follicular-colloidal index, the number of thyrocytes in the follicle and resorption vacuoles in the colloid. Also, the growth of the interfollicular islets number, the reduction of the colloid accumulation index, the decrease of the relative gland stromal area were observed. The rats of the experimental group revealed a moderate growth in the magnesium content in the erythrocyte suspension.Conclusions. Thus, the magnesium chloride ingestion is succeeded by the appearance histomorphological features of the synthetic activity in the thyroid gland.Key words: magnesium, thyroid, morphometric indicators" @default.
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- W2990018548 date "2019-01-01" @default.
- W2990018548 modified "2023-09-25" @default.
- W2990018548 title "Morphological changes in the thyroid gland of rats after magnesium chloride ingestion" @default.
- W2990018548 doi "https://doi.org/10.31088/cem2019.8.3.41-47" @default.
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