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• W2990054146 abstract "The research is part of the planned scientific work of the departments of normal anatomy and operative surgery with topographical anatomy Structural organization, angioarchitectonics and anthropometric features of organs in the internal and extrauterine periods of development, under conditions of exo-endopathogenic factors, the state registration number: 0115U000041, which is executed in Danylo Halytsky Lviv National Medical University according to the state plan and program during 2015-2020. The permission of the Ethics Committee of the Danylo Halytsky Lviv National Medical University (protocol No. 3 dated March 16, 2015) was obtained for the study. Actuality. Bone tissue density is a universal indicator that allows to determine its quality, estimate and predict early quantitative and qualitative changes and trace their dynamics in clinical and experimental conditions. The aim of our study was to find out the regularities of the post-traumatic dynamics of the density of the mandibular bone tissue after performing a bone-destroying injury to intact animals and animals that have been taking nalbuphine for a long time. The study was performed on 20 sexually mature, male rats with a body weight of 180-200 g and a 3.5-month old age. Experimental animals were kept in the vivarium of the Danylo Halytsky Lviv National Medical Universit. All studies were conducted in accordance with the provisions of the European Convention for the protection of vertebrate animals used for experimental and other scientific purposes (Strasbourg, 1986), Council Directive 86/609 / EEC (1986), Law of Ukraine No. 3447-IV On the Protection of Animals from Cruel handling. The injury was modeled by breaking the integrity of the bony tissue of the mandible in the area of mokars with the help of dental drill. The operation was performed under thiopental anesthesia. Opioid dependence was modeled by a daily (once a day at the same time interval) injection of a narcotic analgetic Nalbuphine. Nalbuphine was injected intramuscularly according to the following schedule: 1 week – 8 mg / kg, 2nd week – 15 mg / kg, 3rd week – 20 mg / kg, 4th week – 25 mg / kg, 5 –this week – 30 mg / kg, 6th week – 35 mg / kg. Control of the quality of bone tissue of the mandible in the area of injury was carried out using a dental radiosignographer Siemens with the software Trophy Radiology. The unit of measurement of tissue density was taken to be the conventional unit of gravity (CUG). The quality of mandibular bone tissue was studied in 1, 2 and 3 weeks after injury to intact rats and rats, who had been injected nalbuphine for up to three weeks and continued to receive it for another three weeks after the injury, as well as non-traumatic animals present at different terms of opioid dependence (5 animals per experiment period). Another 5 animals were in the control group. For each group, the arithmetic mean value of the researched indicator, the variance and the confidence interval at the level of reliability of P = 95% were determined. Results. An analysis of the density of bone tissue of the mandible within three weeks after the applicationof the trauma which leads to the bone loss in intact animals made it possible to establish the presence of an expressed dynamics of the investigated indicator. Within two weeks after injury, the density of bone tissue of the mandible in the injured area gradually increases, increasing by the end of the second week twice as much as the norm. During the third week, the investigated parameter is declining, but remains somewhat higher than in intact animals. To determine the peculiarities of changes in the density of bone tissue on the background of prolonged nalbuphine use, the dynamics of the studied parameters for 6 weeks of administration and after its discontinuation was studied. The analysis showed that after two weeks of use of nalbuphine, the density of mandibular bone tissue gradually increased compared to control group, and during the third week it decreased, returning to almost normal values. During the fourth and fifth weeks, the researched parameter increased again, and decreased in the sixth week, remaining unchanged and within a week after discontinuation of the drug. Since the density of the bone tissue of the mandible after three weeks of administration of nalbuphina is as close to normal as possible, this is the term that was selected to perform bone injury on animals that were modeled on nalbuphine (opioid) dependence. The analysis of the data showed that the dynamics of bone density after a bone injury with the use of nalbuphine is quite different from that of intact animals. A week after the trauma, the investigated parameter practically does not change, after two week increases and its rise continues until the end of the experiment. Conclusion. The application of a bone-traumatic injury leads to an expressed dynamics of bone density in the area of the trauma, which testifies a change in its quality. The dynamics of bone density of the mandible after a bone injury with the use of nalbuphine is different from that of intact animals. Three weeks after bone injuries, bone density in intact rats only slightly exceeds the norm, while in animals with opioid dependence, the investigated parameter is twice as high as normal." @default.
• W2990054146 created "2019-12-05" @default.
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• W2990054146 date "2019-01-23" @default.
• W2990054146 modified "2023-09-26" @default.
• W2990054146 title "COMPARISON OF THE POSTTRUMMATIC DYNAMICS OF THE BONE TISSUE DENSITY OF THE LOWER JAW IN THE INTACT RATS AND ON THE BACKGROUND OF THE PERMANENT NALBUFINE USE" @default.
• W2990054146 doi "https://doi.org/10.24061/1727-0847.18.1.2019.5" @default.
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