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- W2990063083 abstract "Tumor necrosis factor receptor superfamilies (TNFRSF) are one of essential cytokines and can trigger inflammation, apoptosis, participating lymphocyte homeostasis and tissue development in vertebrates. To gain insights into the evolution and characterization of tnfr genes in lamprey, a jawless vertebrate, we performed a genome-wide and transcriptome survey and identified 7 tnfr genes in the lamprey (Lethenteron reissneri) database. Based on the molecular phylogenetic analysis, 7 L-tnfr genes are divided into three different clusters, and multiple members of tnfr genes family have appeared in lamprey. Meanwhile, protein domains and motifs analysis reveals that TNFRSF are conserved and have typical cysteine-rich domains (CRDs). Synteny results indicates that the L-tnfr neighborhood genes have taken place great changes compared to jawed vertebrates. Real-time quantitative results demonstrate that tnfr gene family plays an important role in the immune defense. This study has a new understanding for origin and evolution of the tnfr gene family in different vertebrates." @default.
- W2990063083 created "2019-12-05" @default.
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- W2990063083 date "2020-01-01" @default.
- W2990063083 modified "2023-09-24" @default.
- W2990063083 title "Molecular evolution of the tnfr gene family and expression profiles in response to pathogens in lamprey(Lethenteron reissneri)" @default.
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- W2990063083 doi "https://doi.org/10.1016/j.fsi.2019.11.037" @default.
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