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- W2990067553 abstract "Histamine-releasing activities on human basophils have been studied as potential allergy-causing agents for four decades. An IgE-dependent histamine-releasing factor (HRF) was recently shown to interact with a subset of immunoglobulins. Peptides or recombinant proteins that block the interactions between HRF and IgE have emerged as promising anti-allergic therapeutics, as administration of them prevented or ameliorated type 2 inflammation in animal models of allergic diseases such as asthma and food allergy. Basic and clinical studies support the notion that HRF amplifies IgE-mediated activation of mast cells and basophils. We discuss how secreted HRF promotes allergic inflammation in vitro and in vivo complex disease settings." @default.
- W2990067553 created "2019-12-05" @default.
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- W2990067553 date "2019-11-26" @default.
- W2990067553 modified "2023-10-11" @default.
- W2990067553 title "Histamine-Releasing Factor, a New Therapeutic Target in Allergic Diseases" @default.
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- W2990067553 doi "https://doi.org/10.3390/cells8121515" @default.
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