FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990076306> ?p ?o ?g. }

• W2990076306 abstract "ABSTRACT ORPphilins, natural molecules that strongly and selectively inhibit the growth of some cancer cell lines, are proposed to target intracellular lipid-transfer proteins of the Oxysterol-binding protein (OSBP) family. These conserved proteins exchange key lipids, such as cholesterol and phopsphatidylinositol-4-phosphate (PI(4)P), between organelle membranes. Among ORPphilins, molecules of the schweinfurthin family interfere with intracellular lipid distribution and metabolism, but their functioning at the molecular level is poorly understood. We report here that cell line sensitivity to schweinfurthin G (SWG) is inversely proportional to cellular level of OSBP. By taking advantage of the intrinsic fluorescence of SWG, we follow its fate in cell cultures and show that its incorporation at the TGN depends on OSBP cellular abundance. We report that SWG inhibits specifically the lipid exchange cycle of OSBP. As a consequence, post-Golgi trafficking, membrane cholesterol levels and PI(4)P turnover are affected. Finally, we demonstrate the direct binding of SWG into OSBP lipid-binding cavity by intermolecular FRET. Collectively these data describe for the first time a specific and intrinsically fluorescent pharmacological tool to dissect OSBP properties at the cellular and molecular levels." @default.
• W2990076306 created "2019-12-05" @default.
• W2990076306 creator A5007747363 @default.
• W2990076306 creator A5015619870 @default.
• W2990076306 creator A5023977458 @default.
• W2990076306 creator A5039199257 @default.
• W2990076306 creator A5043749537 @default.
• W2990076306 creator A5046236895 @default.
• W2990076306 creator A5047355495 @default.
• W2990076306 creator A5047415675 @default.
• W2990076306 creator A5055911923 @default.
• W2990076306 creator A5056482141 @default.
• W2990076306 creator A5063075739 @default.
• W2990076306 creator A5075938142 @default.
• W2990076306 creator A5078814306 @default.
• W2990076306 creator A5082117105 @default.
• W2990076306 creator A5083285328 @default.
• W2990076306 creator A5083569231 @default.
• W2990076306 date "2019-11-20" @default.
• W2990076306 modified "2023-10-18" @default.
• W2990076306 title "Molecular and cellular dissection of the OSBP cycle through a fluorescent inhibitor" @default.
• W2990076306 cites W1689501805 @default.
• W2990076306 cites W1988913028 @default.
• W2990076306 cites W1996878278 @default.
• W2990076306 cites W2000816162 @default.
• W2990076306 cites W2010378383 @default.
• W2990076306 cites W2017028535 @default.
• W2990076306 cites W2019351415 @default.
• W2990076306 cites W2029461840 @default.
• W2990076306 cites W2029589437 @default.
• W2990076306 cites W2035270506 @default.
• W2990076306 cites W2035727068 @default.
• W2990076306 cites W2048549704 @default.
• W2990076306 cites W2064892346 @default.
• W2990076306 cites W2076128208 @default.
• W2990076306 cites W2094415011 @default.
• W2990076306 cites W2109312693 @default.
• W2990076306 cites W2237057690 @default.
• W2990076306 cites W2283606770 @default.
• W2990076306 cites W2341412675 @default.
• W2990076306 cites W2411730198 @default.
• W2990076306 cites W2508083436 @default.
• W2990076306 cites W2518078251 @default.
• W2990076306 cites W2597223015 @default.
• W2990076306 cites W2761934676 @default.
• W2990076306 cites W2763380116 @default.
• W2990076306 cites W2809238855 @default.
• W2990076306 cites W2897578192 @default.
• W2990076306 cites W2899095807 @default.
• W2990076306 cites W2916121868 @default.
• W2990076306 cites W2924708058 @default.
• W2990076306 cites W2971414127 @default.
• W2990076306 cites W2976971613 @default.
• W2990076306 doi "https://doi.org/10.1101/844548" @default.
• W2990076306 hasPublicationYear "2019" @default.
• W2990076306 type Work @default.
• W2990076306 sameAs 2990076306 @default.
• W2990076306 citedByCount "0" @default.
• W2990076306 crossrefType "posted-content" @default.
• W2990076306 hasAuthorship W2990076306A5007747363 @default.
• W2990076306 hasAuthorship W2990076306A5015619870 @default.
• W2990076306 hasAuthorship W2990076306A5023977458 @default.
• W2990076306 hasAuthorship W2990076306A5039199257 @default.
• W2990076306 hasAuthorship W2990076306A5043749537 @default.
• W2990076306 hasAuthorship W2990076306A5046236895 @default.
• W2990076306 hasAuthorship W2990076306A5047355495 @default.
• W2990076306 hasAuthorship W2990076306A5047415675 @default.
• W2990076306 hasAuthorship W2990076306A5055911923 @default.
• W2990076306 hasAuthorship W2990076306A5056482141 @default.
• W2990076306 hasAuthorship W2990076306A5063075739 @default.
• W2990076306 hasAuthorship W2990076306A5075938142 @default.
• W2990076306 hasAuthorship W2990076306A5078814306 @default.
• W2990076306 hasAuthorship W2990076306A5082117105 @default.
• W2990076306 hasAuthorship W2990076306A5083285328 @default.
• W2990076306 hasAuthorship W2990076306A5083569231 @default.
• W2990076306 hasBestOaLocation W29900763061 @default.
• W2990076306 hasConcept C104317684 @default.
• W2990076306 hasConcept C119062480 @default.
• W2990076306 hasConcept C12554922 @default.
• W2990076306 hasConcept C158617107 @default.
• W2990076306 hasConcept C168240541 @default.
• W2990076306 hasConcept C185592680 @default.
• W2990076306 hasConcept C25095133 @default.
• W2990076306 hasConcept C55493867 @default.
• W2990076306 hasConcept C7251936 @default.
• W2990076306 hasConcept C79879829 @default.
• W2990076306 hasConcept C86803240 @default.
• W2990076306 hasConcept C95444343 @default.
• W2990076306 hasConceptScore W2990076306C104317684 @default.
• W2990076306 hasConceptScore W2990076306C119062480 @default.
• W2990076306 hasConceptScore W2990076306C12554922 @default.
• W2990076306 hasConceptScore W2990076306C158617107 @default.
• W2990076306 hasConceptScore W2990076306C168240541 @default.
• W2990076306 hasConceptScore W2990076306C185592680 @default.
• W2990076306 hasConceptScore W2990076306C25095133 @default.
• W2990076306 hasConceptScore W2990076306C55493867 @default.
• W2990076306 hasConceptScore W2990076306C7251936 @default.
• W2990076306 hasConceptScore W2990076306C79879829 @default.
• W2990076306 hasConceptScore W2990076306C86803240 @default.
• W2990076306 hasConceptScore W2990076306C95444343 @default.

• next