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- W2990091519 abstract "Abstract While studies have reported genetic loci affecting serum urate (SU) concentrations, few studies have been conducted in minority populations. Our objective for this study was to identify genetic loci regulating SU in a multigenerational family-based cohort of American Indians, the Strong Heart Family Study (SHFS). We genotyped 162,718 single nucleotide polymorphisms (SNPs) in 2000 SHFS participants using an Illumina MetaboChip array. A genome-wide association analysis of SU was conducted using measured genotype analysis approach accounting for kinships in SOLAR, and meta-analysis in METAL. Our results showed strong association of SU with rs4481233, rs9998811, rs7696092 and rs13145758 (minor allele frequency (MAF) = 25–44%; P < 3 × 10 −14 ) of solute carrier family 2, member 9 ( SLC2A9 ) and rs41481455, rs2231142 and rs1481012 (MAF = 29%; p < 3 × 10 −9 ) of ATP-binding cassette protein, subfamily G, member 2 ( ABCG2 ). Carriers of G alleles of rs9998811, rs4148155 and rs1481012 and A alleles of rs4481233, rs7696092 and rs13145758 and rs2231142 had lower SU concentrations as compared to non-carriers. Genetic analysis of SU conditional on significant SLC2A9 and ABCG2 SNPs revealed new loci, nucleobindin 1 ( NUCB1 ) and neuronal PAS domain protein 4 ( NPAS4 ) (p <6× 10 −6 ). To identify American Indian-specific SNPs, we conducted targeted sequencing of key regions of SLC2A9 . A total of 233 SNPs were identified of which 89 were strongly associated with SU (p < 7.1 × 10 −10 ) and 117 were American Indian specific. Analysis of key SNPs in cohorts of Mexican-mestizos, European, Indian and East Asian ancestries showed replication of common SNPs, including our lead SNPs. Our results demonstrate the association of SU with uric acid transporters in a minority population of American Indians and potential novel associations of SU with neuronal-related genes which warrant further investigation." @default.
- W2990091519 created "2019-12-05" @default.
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- W2990091519 date "2019-11-29" @default.
- W2990091519 modified "2023-10-17" @default.
- W2990091519 title "Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study" @default.
- W2990091519 cites W1755596743 @default.
- W2990091519 cites W1963655976 @default.
- W2990091519 cites W1968258789 @default.
- W2990091519 cites W1974858693 @default.
- W2990091519 cites W1975906479 @default.
- W2990091519 cites W1999819760 @default.
- W2990091519 cites W2002921831 @default.
- W2990091519 cites W2012846657 @default.
- W2990091519 cites W2014934291 @default.
- W2990091519 cites W2016767399 @default.
- W2990091519 cites W2030361670 @default.
- W2990091519 cites W2031296193 @default.
- W2990091519 cites W2039768312 @default.
- W2990091519 cites W2044853803 @default.
- W2990091519 cites W2048578647 @default.
- W2990091519 cites W2055300468 @default.
- W2990091519 cites W2055392121 @default.
- W2990091519 cites W2065402200 @default.
- W2990091519 cites W2066765810 @default.
- W2990091519 cites W2074214095 @default.
- W2990091519 cites W2083068560 @default.
- W2990091519 cites W2089357919 @default.
- W2990091519 cites W2089914064 @default.
- W2990091519 cites W2091437086 @default.
- W2990091519 cites W2092270029 @default.
- W2990091519 cites W2095820576 @default.
- W2990091519 cites W2096468806 @default.
- W2990091519 cites W2103115460 @default.
- W2990091519 cites W2104549677 @default.
- W2990091519 cites W2108466633 @default.
- W2990091519 cites W2111355325 @default.
- W2990091519 cites W2112361691 @default.
- W2990091519 cites W2115335486 @default.
- W2990091519 cites W2116297982 @default.
- W2990091519 cites W2119180969 @default.
- W2990091519 cites W2122302405 @default.
- W2990091519 cites W2123411711 @default.
- W2990091519 cites W2133200119 @default.
- W2990091519 cites W2133520037 @default.
- W2990091519 cites W2134073450 @default.
- W2990091519 cites W2134460361 @default.
- W2990091519 cites W2138745111 @default.
- W2990091519 cites W2140972828 @default.
- W2990091519 cites W2142614156 @default.
- W2990091519 cites W2146822394 @default.
- W2990091519 cites W2147452548 @default.
- W2990091519 cites W2148704941 @default.
- W2990091519 cites W2152885121 @default.
- W2990091519 cites W2155420663 @default.
- W2990091519 cites W2157752701 @default.
- W2990091519 cites W2159295592 @default.
- W2990091519 cites W2161633633 @default.
- W2990091519 cites W2166174569 @default.
- W2990091519 cites W2169629898 @default.
- W2990091519 cites W2170624664 @default.
- W2990091519 cites W2229043823 @default.
- W2990091519 cites W2273161154 @default.
- W2990091519 cites W2317276390 @default.
- W2990091519 cites W2337785552 @default.
- W2990091519 cites W2398091221 @default.
- W2990091519 cites W2526157234 @default.
- W2990091519 cites W2559250903 @default.
- W2990091519 cites W2560052944 @default.
- W2990091519 cites W2565162239 @default.
- W2990091519 cites W2587257410 @default.
- W2990091519 cites W2591110932 @default.
- W2990091519 cites W2621671248 @default.
- W2990091519 cites W2737066923 @default.
- W2990091519 cites W2765123335 @default.
- W2990091519 cites W2789833091 @default.
- W2990091519 cites W2807450709 @default.
- W2990091519 cites W2884325069 @default.
- W2990091519 cites W2893178924 @default.
- W2990091519 cites W2899111966 @default.
- W2990091519 cites W2899626692 @default.
- W2990091519 cites W80528565 @default.
- W2990091519 doi "https://doi.org/10.1038/s41598-019-52924-w" @default.