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• W2990101312 abstract "A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD ( At HPPD) inhibitors, in particular compounds I12 ( K i = 0.011 µM) and I23 ( K i = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide ( K i = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound II4 was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification." @default.
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• W2990101312 date "2020-02-19" @default.
• W2990101312 modified "2023-10-16" @default.
• W2990101312 title "Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors" @default.
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• W2990101312 doi "https://doi.org/10.3762/bjoc.16.25" @default.
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