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- W2990101464 abstract "Background: Non-invasive ventilation (NIV) in amyotrophic lateral sclerosis (ALS) increases survival and improves patients (pts) quality of life. A decrease in forced vital capacity (FVC) or maximal inspiratory pressure (PImax) have been used to define the timing to initiate NIV. Aims: To identify predicting factors of respiratory impairment with formal criteria for the start of NIV (FVC≤70 in % of predicted value or PImax Methods: Clinical data regarding to pts diagnosed with ALS were reviewed. Demographic and clinical parameters were compared to pulmonary function tests, dividing the pts between those with FVC≤70 or >70 and PImax Results: 53 patients were selected, 28 (53%) males, mean age at diagnosis 66. 21 pts (40%) had FVC≤70; 37 pts (70%) had PImax 70 (21 months VS 34; p=0,03); there was no statistically significant difference between the groups with PImax Conclusion: Disease presentation at older ages and with bulbar symptoms may correlate with early respiratory impairment suggesting the need for early referral to pulmonology." @default.
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- W2990101464 date "2019-09-28" @default.
- W2990101464 modified "2023-09-25" @default.
- W2990101464 title "Amyotrophic lateral sclerosis: predictors of respiratory impairment at disease diagnosis" @default.
- W2990101464 doi "https://doi.org/10.1183/13993003.congress-2019.pa808" @default.
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