FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990103552> ?p ?o ?g. }

• W2990103552 abstract "Abstract Background Cardiovascular disease (CVD) is considered a major cause of death in renal insufficiency (RI). Contributing genetic factors is a recent focus of research. This study aims to elucidate apolipoprotein E (APO-E) and plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms in RI children associated with CVD. Methods We studied 50 cases with chronic kidney disease (CKD) associated with CVD, and 30 healthy controls. Study sample was grouped as one on conservative treatment, the second on hemodialysis and the third was posttransplant. PAI-1 and APO-E gene polymorphisms were investigated using allele-specific polymerase chain reaction (AS-PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) respectively. Results 4G4G and 4G5G were the most common PAI-1 polymorphism denoting high association of 4 G allele in renal insufficiency associated with CVD with absent link to dyslipidemia, echocardiography changes or thrombosis. E3E3 was the most common among APO-E polymorphism without relation to dyslipidemia or thrombosis. Dyslipidemia was significantly linked to thrombosis. The study confirmed the role of dyslipidemia and hemodialysis in promoting thrombosis. Conclusion Although PAI 4G Genotyping did not show significant association with echocardiography severity or thrombotic severity, yet genetic expression for high levels of PAI in plasma is expected in response to CRI factors known to trigger its release, in addition to those related to dialysis. APO-E3E3 genotyping showed a significant association with echocardiography severity as it enhances APO-A which contributes to CVD. The current study confirmed a significant association between dyslipidemia and CVD; however, the prevalent patterns 4G and E3E3 did not show a significant association with dyslipidemia. The genetic role for APO-A, B, O, or even other isomers for APO-E should be further studied as well." @default.
• W2990103552 created "2019-12-05" @default.
• W2990103552 creator A5027826397 @default.
• W2990103552 creator A5035247340 @default.
• W2990103552 creator A5053740351 @default.
• W2990103552 creator A5068504548 @default.
• W2990103552 creator A5087910830 @default.
• W2990103552 date "2019-11-27" @default.
• W2990103552 modified "2023-09-25" @default.
• W2990103552 title "Apolipoprotein E and plasminogen activator inhibitor 1 gene polymorphism in children with chronic renal insufficiency associated with cardiovascular disease" @default.
• W2990103552 cites W1965430426 @default.
• W2990103552 cites W1969997949 @default.
• W2990103552 cites W1986591284 @default.
• W2990103552 cites W1987719260 @default.
• W2990103552 cites W1992255677 @default.
• W2990103552 cites W2009767037 @default.
• W2990103552 cites W2010039024 @default.
• W2990103552 cites W2023216924 @default.
• W2990103552 cites W2024580539 @default.
• W2990103552 cites W2029247791 @default.
• W2990103552 cites W2032444690 @default.
• W2990103552 cites W2034563271 @default.
• W2990103552 cites W2042425725 @default.
• W2990103552 cites W2051612201 @default.
• W2990103552 cites W2052061168 @default.
• W2990103552 cites W2054239245 @default.
• W2990103552 cites W2055014080 @default.
• W2990103552 cites W2079007905 @default.
• W2990103552 cites W2080508595 @default.
• W2990103552 cites W2090372047 @default.
• W2990103552 cites W2092576380 @default.
• W2990103552 cites W2101692513 @default.
• W2990103552 cites W2112915277 @default.
• W2990103552 cites W2116284648 @default.
• W2990103552 cites W2117793704 @default.
• W2990103552 cites W2117931787 @default.
• W2990103552 cites W2121317998 @default.
• W2990103552 cites W2121719509 @default.
• W2990103552 cites W2126359017 @default.
• W2990103552 cites W2126644103 @default.
• W2990103552 cites W2130629729 @default.
• W2990103552 cites W2136094514 @default.
• W2990103552 cites W2138620116 @default.
• W2990103552 cites W2145399033 @default.
• W2990103552 cites W2148081733 @default.
• W2990103552 cites W2158289184 @default.
• W2990103552 cites W2158745632 @default.
• W2990103552 cites W2319467927 @default.
• W2990103552 cites W2336672206 @default.
• W2990103552 cites W4241508796 @default.
• W2990103552 doi "https://doi.org/10.1186/s43054-019-0011-9" @default.
• W2990103552 hasPublicationYear "2019" @default.
• W2990103552 type Work @default.
• W2990103552 sameAs 2990103552 @default.
• W2990103552 citedByCount "0" @default.
• W2990103552 crossrefType "journal-article" @default.
• W2990103552 hasAuthorship W2990103552A5027826397 @default.
• W2990103552 hasAuthorship W2990103552A5035247340 @default.
• W2990103552 hasAuthorship W2990103552A5053740351 @default.
• W2990103552 hasAuthorship W2990103552A5068504548 @default.
• W2990103552 hasAuthorship W2990103552A5087910830 @default.
• W2990103552 hasBestOaLocation W29901035521 @default.
• W2990103552 hasConcept C104317684 @default.
• W2990103552 hasConcept C126322002 @default.
• W2990103552 hasConcept C135763542 @default.
• W2990103552 hasConcept C180754005 @default.
• W2990103552 hasConcept C203014093 @default.
• W2990103552 hasConcept C2778063415 @default.
• W2990103552 hasConcept C2778096610 @default.
• W2990103552 hasConcept C2778163477 @default.
• W2990103552 hasConcept C2779134260 @default.
• W2990103552 hasConcept C2779679481 @default.
• W2990103552 hasConcept C2780675426 @default.
• W2990103552 hasConcept C2780868729 @default.
• W2990103552 hasConcept C31467283 @default.
• W2990103552 hasConcept C54355233 @default.
• W2990103552 hasConcept C57089818 @default.
• W2990103552 hasConcept C62746215 @default.
• W2990103552 hasConcept C71924100 @default.
• W2990103552 hasConcept C86803240 @default.
• W2990103552 hasConcept C90924648 @default.
• W2990103552 hasConceptScore W2990103552C104317684 @default.
• W2990103552 hasConceptScore W2990103552C126322002 @default.
• W2990103552 hasConceptScore W2990103552C135763542 @default.
• W2990103552 hasConceptScore W2990103552C180754005 @default.
• W2990103552 hasConceptScore W2990103552C203014093 @default.
• W2990103552 hasConceptScore W2990103552C2778063415 @default.
• W2990103552 hasConceptScore W2990103552C2778096610 @default.
• W2990103552 hasConceptScore W2990103552C2778163477 @default.
• W2990103552 hasConceptScore W2990103552C2779134260 @default.
• W2990103552 hasConceptScore W2990103552C2779679481 @default.
• W2990103552 hasConceptScore W2990103552C2780675426 @default.
• W2990103552 hasConceptScore W2990103552C2780868729 @default.
• W2990103552 hasConceptScore W2990103552C31467283 @default.
• W2990103552 hasConceptScore W2990103552C54355233 @default.
• W2990103552 hasConceptScore W2990103552C57089818 @default.
• W2990103552 hasConceptScore W2990103552C62746215 @default.
• W2990103552 hasConceptScore W2990103552C71924100 @default.
• W2990103552 hasConceptScore W2990103552C86803240 @default.
• W2990103552 hasConceptScore W2990103552C90924648 @default.

• next