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- W2990133107 abstract "Abstract Background The western corn rootworm, Diabrotica virgifera virgifera , is a pervasive pest of maize in North America and Europe, which has adapted to current pest management strategies. In advance of an assembled and annotated D. v. virgifera genome, we developed transcriptomic resources to use in identifying candidate genes likely to be involved in the evolution of resistance, starting with members of the ATP-binding cassette (ABC) transporter family. Results In this study, 65 putative D. v. virgifera ABC ( Dvv ABC) transporters were identified within a combined transcriptome assembly generated from embryonic, larval, adult male, and adult female RNA-sequence libraries. Phylogenetic analysis placed the deduced amino-acid sequences of the Dvv ABC transporters into eight subfamilies (A to H). To supplement our sequence data with functional analysis, we identified orthologs of Tribolium castaneum ABC genes which had previously been shown to exhibit overt RNA interference (RNAi) phenotypes. We identified eight such D. v. virgifera genes, and found that they were functionally similar to their T. castaneum counterparts. Interestingly, depletion of DvvABCB_39715 and DvvABCG_3712 transcripts in adult females produced detrimental reproductive and developmental phenotypes, demonstrating the potential of these genes as targets for RNAi-mediated insect control tactics. Conclusions By combining sequence data from four libraries covering three distinct life stages, we have produced a relatively comprehensive de novo transcriptome assembly for D. v. virgifera . Moreover, we have identified 65 members of the ABC transporter family and provided the first insights into the developmental and physiological roles of ABC transporters in this pest species." @default.
- W2990133107 created "2019-12-05" @default.
- W2990133107 creator A5003073666 @default.
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- W2990133107 date "2019-11-27" @default.
- W2990133107 modified "2023-10-09" @default.
- W2990133107 title "Structural and functional insights into the Diabrotica virgifera virgifera ATP-binding cassette transporter gene family" @default.
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- W2990133107 doi "https://doi.org/10.1186/s12864-019-6218-8" @default.
- W2990133107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6882327" @default.
- W2990133107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31775611" @default.
- W2990133107 hasPublicationYear "2019" @default.
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