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• W2990162666 endingPage "1450" @default.
• W2990162666 startingPage "1437" @default.
• W2990162666 abstract "The airways of persons with cystic fibrosis are prone to infection by a diverse and dynamic polymicrobial consortium. Currently, no models exist that permit recapitulation of this consortium within the laboratory. Such microbial ecosystems likely have a network of interspecies interactions, serving to modulate metabolic pathways and impact upon disease severity. The contribution of less abundant/fastidious microbial species on this cross-talk has often been neglected due to lack of experimental tractability. Here, we critically assess the existing models for studying polymicrobial infections. Particular attention is paid to 3Rs-compliant in vitro and in silico infection models, offering significant advantages over mammalian infection models. We outline why these models will likely become the 'go to' approaches when recapitulating polymicrobial cystic fibrosis infection." @default.
• W2990162666 created "2019-12-05" @default.
• W2990162666 creator A5057438504 @default.
• W2990162666 creator A5083321505 @default.
• W2990162666 date "2019-11-01" @default.
• W2990162666 modified "2023-09-23" @default.
• W2990162666 title "Recapitulation of polymicrobial communities associated with cystic fibrosis airway infections: a perspective" @default.
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• W2990162666 doi "https://doi.org/10.2217/fmb-2019-0200" @default.
• W2990162666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31778075" @default.

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