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• W2990164009 abstract "High-altitude (HA) hypoxia exposure is believed to induce venous thromboembolism (VTE) in otherwise healthy individuals, although this needs to be fully established. The present study aims to ascertain the role of HA exposure in aggravating any predisposition toward VTE and to explore whether the etiology of HA-induced VTE is different from that of VTE closer to sea level. We compared manifestation-matched male VTE patients from HA (HAPs) and VTE patients from the plains closer to sea level (SLPs) for 54 parameters, including coagulation-related, fibrinolytic, and thrombophilic variables, as well as markers for stress and inflammatory response and platelet and endothelial activation. Our results established an association between HA hypoxia and VTE in alterations of primarily hemostatic variables. Approximately 96% of HAPs presented with ≥10 altered parameters out of 54 studied compared with 7% of SLPs. Elevated platelet count, von Willebrand factor, and clotting factors and altered coagulation exhibited significant associations with VTE events and altitude exposure (all P < .05). Additionally, most VTEs at HA were associated with younger age groups, unlike those on the plains. A receiver operator characteristic curve analysis revealed differences between HAPs and SLPs for CD40 ligand (area under the curve [AUC], 0.90; 95% confidence interval [CI], 0.84-0.96]), P-selectin (0.79; 0.70-0.88), platelet factor-4 (0.90; 0.84-0.96), intracellular adhesion molecule-1 (0.86; 0.79-0.93), vascular cell adhesion molecule-1 (0.97; 0.95-0.99), vascular endothelial growth factor (0.87; 0.8-0.94), FLT4 (0.94; 0.89-0.99), and Toll-like receptor-2 (0.98; 0.96-1.0) (all P < .05). In conclusion, this study suggests that HA exposure perturbs the molecules associated with vascular integrity and contributes to the early onset of VTE." @default.
• W2990164009 created "2019-12-05" @default.
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• W2990164009 date "2019-11-25" @default.
• W2990164009 modified "2023-10-17" @default.
• W2990164009 title "Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains" @default.
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• W2990164009 cites W1971035955 @default.
• W2990164009 cites W1977126833 @default.
• W2990164009 cites W1979700577 @default.
• W2990164009 cites W1980669153 @default.
• W2990164009 cites W1980738292 @default.
• W2990164009 cites W198418484 @default.
• W2990164009 cites W1987447695 @default.
• W2990164009 cites W1987677883 @default.
• W2990164009 cites W1988212011 @default.
• W2990164009 cites W1998587301 @default.
• W2990164009 cites W2002078393 @default.
• W2990164009 cites W2003768002 @default.
• W2990164009 cites W2006739637 @default.
• W2990164009 cites W2007684714 @default.
• W2990164009 cites W2019746767 @default.
• W2990164009 cites W2022899744 @default.
• W2990164009 cites W2032527946 @default.
• W2990164009 cites W2046429224 @default.
• W2990164009 cites W2046644549 @default.
• W2990164009 cites W2046754064 @default.
• W2990164009 cites W2050360907 @default.
• W2990164009 cites W2054540030 @default.
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• W2990164009 cites W2097016664 @default.
• W2990164009 cites W2097539258 @default.
• W2990164009 cites W2100090535 @default.
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• W2990164009 cites W2141860697 @default.
• W2990164009 cites W2145575675 @default.
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• W2990164009 cites W2160621818 @default.
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• W2990164009 cites W2176628617 @default.
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• W2990164009 cites W2229879825 @default.
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• W2990164009 cites W2329228559 @default.
• W2990164009 cites W2331687326 @default.
• W2990164009 cites W2339851248 @default.
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• W2990164009 doi "https://doi.org/10.1182/bloodadvances.2018024554" @default.
• W2990164009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6880906" @default.
• W2990164009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31765479" @default.
• W2990164009 hasPublicationYear "2019" @default.
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