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- W2990165307 abstract "To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer.A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed.SMC4 mRNA level was significantly upregulated in breast cancer tissues (P < 0.001). Patients with high mRNA expression of SMC4 had significantly poor survival (P = 0.012). Subgroup analyses show that in nontriple negative breast cancer (non-TNBC) patients, the high SMC4 mRNA expression, older age (>65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (HR = 3.293, 95% CI 1.257-8.625, P = 0.015). In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate (P < 0.046).SMC4 mRNA level is a good prognostic biomarker for patients with breast cancer." @default.
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- W2990165307 date "2019-11-21" @default.
- W2990165307 modified "2023-10-10" @default.
- W2990165307 title "The Prognostic Value of the Expression of <i>SMC4</i> mRNA in Breast Cancer" @default.
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- W2990165307 doi "https://doi.org/10.1155/2019/2183057" @default.
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