FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990184455> ?p ?o ?g. }

• W2990184455 abstract "Hyperkalemia is a major cause of on-site death in crush syndrome (CS), which is more severe and common in male victims. Anisodamine is a belladonna alkaloid and widely used in China for treatment of shock through activation of α7 nicotinic acetylcholine receptor (α7nAChR). The present work was designed to study the protective effect of anisodamine in CS and the possible role of estradiol involved. Male and ovariectomized female CS mice exhibited lower serum estradiol and insulin sensitivity, and higher potassium compared to the relative female controls at 6 h after decompression. There was no gender difference in on-site mortality in CS mice within 24 h after decompression. Serum estradiol increased with similar values in CS mice of both gender compared to that in normal mice. Anisodamine decreased serum potassium and increased serum estradiol and insulin sensitivity in CS mice, and methyllycaconitine, selective antagonist of α7nAChR, counteracted such effects of anisodamine. Treatment with anisodamine or estradiol increased serum estradiol and insulin sensitivity, decreased serum potassium and on-site mortality, and eliminated the difference in these parameters between CS mice received ovariectomy or its sham operation. Anisodamine could also increase blood pressure in CS rats within 3.5 h after decompression, which could also be attenuated by methyllycaconitine, without influences on heart rate. These results suggest that activation of α7nAChR with anisodamine could decrease serum potassium and on-site mortality in CS through estradiol-induced enhancement of insulin sensitivity." @default.
• W2990184455 created "2019-12-05" @default.
• W2990184455 creator A5034266315 @default.
• W2990184455 creator A5054586388 @default.
• W2990184455 creator A5055421408 @default.
• W2990184455 creator A5056119388 @default.
• W2990184455 creator A5064403347 @default.
• W2990184455 creator A5090266554 @default.
• W2990184455 date "2019-11-29" @default.
• W2990184455 modified "2023-10-01" @default.
• W2990184455 title "Anisodamine Ameliorates Hyperkalemia during Crush Syndrome through Estradiol-Induced Enhancement of Insulin Sensitivity" @default.
• W2990184455 cites W1186444048 @default.
• W2990184455 cites W1916829096 @default.
• W2990184455 cites W1964020323 @default.
• W2990184455 cites W1975084142 @default.
• W2990184455 cites W1975890773 @default.
• W2990184455 cites W1978605914 @default.
• W2990184455 cites W1982653181 @default.
• W2990184455 cites W1998167013 @default.
• W2990184455 cites W2015198780 @default.
• W2990184455 cites W2021759517 @default.
• W2990184455 cites W2046900647 @default.
• W2990184455 cites W2056288777 @default.
• W2990184455 cites W2065442340 @default.
• W2990184455 cites W2067222116 @default.
• W2990184455 cites W2073811267 @default.
• W2990184455 cites W2085026395 @default.
• W2990184455 cites W2105552847 @default.
• W2990184455 cites W2107411150 @default.
• W2990184455 cites W2112054592 @default.
• W2990184455 cites W2147900436 @default.
• W2990184455 cites W2157704281 @default.
• W2990184455 cites W2160470364 @default.
• W2990184455 cites W2170674695 @default.
• W2990184455 cites W2171581543 @default.
• W2990184455 cites W2223009829 @default.
• W2990184455 cites W2251356121 @default.
• W2990184455 cites W2315290435 @default.
• W2990184455 cites W2327940391 @default.
• W2990184455 cites W2419553611 @default.
• W2990184455 cites W2587934962 @default.
• W2990184455 cites W2591044146 @default.
• W2990184455 cites W2611802513 @default.
• W2990184455 cites W2766307829 @default.
• W2990184455 cites W2768426940 @default.
• W2990184455 cites W2795068742 @default.
• W2990184455 cites W2883197899 @default.
• W2990184455 cites W2903378764 @default.
• W2990184455 cites W4378780722 @default.
• W2990184455 cites W60763495 @default.
• W2990184455 doi "https://doi.org/10.3389/fphar.2019.01444" @default.
• W2990184455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6902024" @default.
• W2990184455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31849684" @default.
• W2990184455 hasPublicationYear "2019" @default.
• W2990184455 type Work @default.
• W2990184455 sameAs 2990184455 @default.
• W2990184455 citedByCount "4" @default.
• W2990184455 countsByYear W29901844552020 @default.
• W2990184455 countsByYear W29901844552022 @default.
• W2990184455 countsByYear W29901844552023 @default.
• W2990184455 crossrefType "journal-article" @default.
• W2990184455 hasAuthorship W2990184455A5034266315 @default.
• W2990184455 hasAuthorship W2990184455A5054586388 @default.
• W2990184455 hasAuthorship W2990184455A5055421408 @default.
• W2990184455 hasAuthorship W2990184455A5056119388 @default.
• W2990184455 hasAuthorship W2990184455A5064403347 @default.
• W2990184455 hasAuthorship W2990184455A5090266554 @default.
• W2990184455 hasBestOaLocation W29901844551 @default.
• W2990184455 hasConcept C126322002 @default.
• W2990184455 hasConcept C134018914 @default.
• W2990184455 hasConcept C170493617 @default.
• W2990184455 hasConcept C188987157 @default.
• W2990184455 hasConcept C2777164284 @default.
• W2990184455 hasConcept C2779306644 @default.
• W2990184455 hasConcept C2779570518 @default.
• W2990184455 hasConcept C2779686630 @default.
• W2990184455 hasConcept C2780243291 @default.
• W2990184455 hasConcept C2780374058 @default.
• W2990184455 hasConcept C71924100 @default.
• W2990184455 hasConcept C8264082 @default.
• W2990184455 hasConceptScore W2990184455C126322002 @default.
• W2990184455 hasConceptScore W2990184455C134018914 @default.
• W2990184455 hasConceptScore W2990184455C170493617 @default.
• W2990184455 hasConceptScore W2990184455C188987157 @default.
• W2990184455 hasConceptScore W2990184455C2777164284 @default.
• W2990184455 hasConceptScore W2990184455C2779306644 @default.
• W2990184455 hasConceptScore W2990184455C2779570518 @default.
• W2990184455 hasConceptScore W2990184455C2779686630 @default.
• W2990184455 hasConceptScore W2990184455C2780243291 @default.
• W2990184455 hasConceptScore W2990184455C2780374058 @default.
• W2990184455 hasConceptScore W2990184455C71924100 @default.
• W2990184455 hasConceptScore W2990184455C8264082 @default.
• W2990184455 hasLocation W29901844551 @default.
• W2990184455 hasLocation W29901844552 @default.
• W2990184455 hasLocation W29901844553 @default.
• W2990184455 hasLocation W29901844554 @default.
• W2990184455 hasOpenAccess W2990184455 @default.
• W2990184455 hasPrimaryLocation W29901844551 @default.
• W2990184455 hasRelatedWork W1981503997 @default.
• W2990184455 hasRelatedWork W1995863458 @default.

• next