FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990185257> ?p ?o ?g. }

• W2990185257 endingPage "8" @default.
• W2990185257 startingPage "1" @default.
• W2990185257 abstract "While cytokines and their genetic variants have been intensively studied in schizophrenia, little attention has been focused on chemokines in the last years. The monocyte chemoattractant protein 1 (MCP-1) is known to attract peripheral monocytes to the brain during an inflammatory reaction and to affect the T helper (Th) cell development by stimulating Th2 polarization. Owing to the neuroinflammation in schizophrenia and the variable level of MCP-1 in these patients’ sera, we proposed to analyze the impact of functional genetic variants of the MCP-1 gene (MCP-1-2518A/G (rs1024611), MCP-1-362G/C (rs2857656), and MCP-1 int1del554-567 (rs3917887)) in schizophrenic patients. We conducted a case-control study on a Tunisian population composed of 200 patients and 200 controls using RFLP-PCR. Our results indicated that the minor alleles (-2518G and Del554-567) were significantly more prevalent in controls than in patients (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>/adjusted OR = 0.42,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:mrow></mml:math>/adjusted OR = 0.64), whereas, for -362C minor allele, increased risk of schizophrenia was revealed (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>, adjusted OR = 2.38). In conclusion, we have identified the haplotype combination -2581G/-362G/int1del554-567 that could mediate protection against schizophrenia (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0038</mml:mn></mml:mrow></mml:math>, OR = 0.19) and the effect could result more strongly from the MCP-1 -2582G with -362G variants, whereas the effect of int1del554-567 may in part be explained by its LD with -362." @default.
• W2990185257 created "2019-12-05" @default.
• W2990185257 creator A5001846120 @default.
• W2990185257 creator A5039075424 @default.
• W2990185257 creator A5042066214 @default.
• W2990185257 creator A5053712488 @default.
• W2990185257 creator A5073728946 @default.
• W2990185257 creator A5084172684 @default.
• W2990185257 creator A5090097377 @default.
• W2990185257 date "2019-12-02" @default.
• W2990185257 modified "2023-10-01" @default.
• W2990185257 title "Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia" @default.
• W2990185257 cites W11911259 @default.
• W2990185257 cites W1508506082 @default.
• W2990185257 cites W1608043318 @default.
• W2990185257 cites W1790197493 @default.
• W2990185257 cites W1905242322 @default.
• W2990185257 cites W1971276820 @default.
• W2990185257 cites W1972296893 @default.
• W2990185257 cites W1977707278 @default.
• W2990185257 cites W1979223116 @default.
• W2990185257 cites W1990417242 @default.
• W2990185257 cites W1995865579 @default.
• W2990185257 cites W2005140179 @default.
• W2990185257 cites W2009219530 @default.
• W2990185257 cites W2011464032 @default.
• W2990185257 cites W2011815185 @default.
• W2990185257 cites W2014944455 @default.
• W2990185257 cites W2017852917 @default.
• W2990185257 cites W2026384400 @default.
• W2990185257 cites W2027918830 @default.
• W2990185257 cites W2032208151 @default.
• W2990185257 cites W2035350431 @default.
• W2990185257 cites W2035611331 @default.
• W2990185257 cites W2036825944 @default.
• W2990185257 cites W2040507152 @default.
• W2990185257 cites W2042755650 @default.
• W2990185257 cites W2042777480 @default.
• W2990185257 cites W2045381879 @default.
• W2990185257 cites W2047554790 @default.
• W2990185257 cites W2048363612 @default.
• W2990185257 cites W2049147617 @default.
• W2990185257 cites W2055081835 @default.
• W2990185257 cites W2059738973 @default.
• W2990185257 cites W2060896193 @default.
• W2990185257 cites W2061631515 @default.
• W2990185257 cites W2065892131 @default.
• W2990185257 cites W2067267561 @default.
• W2990185257 cites W2068931506 @default.
• W2990185257 cites W2069151796 @default.
• W2990185257 cites W2077890478 @default.
• W2990185257 cites W2088163583 @default.
• W2990185257 cites W2090804892 @default.
• W2990185257 cites W2092460680 @default.
• W2990185257 cites W2095625105 @default.
• W2990185257 cites W2097086441 @default.
• W2990185257 cites W2102296619 @default.
• W2990185257 cites W2105210680 @default.
• W2990185257 cites W2117102428 @default.
• W2990185257 cites W2123008156 @default.
• W2990185257 cites W2127513692 @default.
• W2990185257 cites W2129730344 @default.
• W2990185257 cites W2162530578 @default.
• W2990185257 cites W2255138985 @default.
• W2990185257 cites W2275706408 @default.
• W2990185257 cites W2367002476 @default.
• W2990185257 cites W2408209465 @default.
• W2990185257 cites W2803065697 @default.
• W2990185257 cites W2888619988 @default.
• W2990185257 doi "https://doi.org/10.1155/2019/4042615" @default.
• W2990185257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6925699" @default.
• W2990185257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31886209" @default.
• W2990185257 hasPublicationYear "2019" @default.
• W2990185257 type Work @default.
• W2990185257 sameAs 2990185257 @default.
• W2990185257 citedByCount "6" @default.
• W2990185257 countsByYear W29901852572021 @default.
• W2990185257 countsByYear W29901852572022 @default.
• W2990185257 countsByYear W29901852572023 @default.
• W2990185257 crossrefType "journal-article" @default.
• W2990185257 hasAuthorship W2990185257A5001846120 @default.
• W2990185257 hasAuthorship W2990185257A5039075424 @default.
• W2990185257 hasAuthorship W2990185257A5042066214 @default.
• W2990185257 hasAuthorship W2990185257A5053712488 @default.
• W2990185257 hasAuthorship W2990185257A5073728946 @default.
• W2990185257 hasAuthorship W2990185257A5084172684 @default.
• W2990185257 hasAuthorship W2990185257A5090097377 @default.
• W2990185257 hasBestOaLocation W29901852571 @default.
• W2990185257 hasConcept C104317684 @default.
• W2990185257 hasConcept C157410074 @default.
• W2990185257 hasConcept C180754005 @default.
• W2990185257 hasConcept C2908647359 @default.
• W2990185257 hasConcept C37463918 @default.
• W2990185257 hasConcept C54355233 @default.
• W2990185257 hasConcept C71924100 @default.
• W2990185257 hasConcept C86803240 @default.
• W2990185257 hasConcept C99454951 @default.
• W2990185257 hasConceptScore W2990185257C104317684 @default.

• next