Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990204585> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2990204585 abstract "Moonlighting refers to a protein with at least two unrelated, mechanistically different functions. As a concept, moonlighting describes a large and diverse group of proteins which have been discovered in a multitude of organisms. As of today, a systematized view on these proteins is missing. Here, we propose a classification of moonlighting proteins by two classifiers. We use the function of the protein as a first classifier: activating - activating (Type I), activating - inhibiting (Type II), inhibiting - activating (Type III) and inhibiting - inhibiting (Type IV). To further specify the type of moonlighting protein, we used a second classifier based on the character of the factor that switches the function of the protein: external factor affecting the protein (Type A), change in the first pathway (Type B), change in the second pathway (Type C), equal competition between both pathways (Type D). Using a small two-pathway model we simulated these types of moonlighting proteins to elucidate possible behaviors of the types of moonlighting proteins. We find that, using the results of our simulations, we can classify the behavior of the moonlighting types into Blinker, Splitter andSwitch." @default.
- W2990204585 created "2019-12-05" @default.
- W2990204585 creator A5003799374 @default.
- W2990204585 creator A5067310765 @default.
- W2990204585 date "2019-11-23" @default.
- W2990204585 modified "2023-10-17" @default.
- W2990204585 title "Moonlighting proteins - an approach to systematize the concept" @default.
- W2990204585 cites W1594056720 @default.
- W2990204585 cites W1976014101 @default.
- W2990204585 cites W1985857203 @default.
- W2990204585 cites W1992625839 @default.
- W2990204585 cites W2045162708 @default.
- W2990204585 cites W2055406318 @default.
- W2990204585 cites W2069694136 @default.
- W2990204585 cites W2089119194 @default.
- W2990204585 cites W2090551173 @default.
- W2990204585 cites W2094089340 @default.
- W2990204585 cites W2106362845 @default.
- W2990204585 cites W2123356497 @default.
- W2990204585 cites W2146885685 @default.
- W2990204585 cites W2148711203 @default.
- W2990204585 cites W2160822774 @default.
- W2990204585 cites W2162605176 @default.
- W2990204585 cites W2163667029 @default.
- W2990204585 cites W2169875902 @default.
- W2990204585 cites W2472022668 @default.
- W2990204585 cites W2518513063 @default.
- W2990204585 doi "https://doi.org/10.3233/isb-190473" @default.
- W2990204585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7505007" @default.
- W2990204585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32285845" @default.
- W2990204585 hasPublicationYear "2019" @default.
- W2990204585 type Work @default.
- W2990204585 sameAs 2990204585 @default.
- W2990204585 citedByCount "3" @default.
- W2990204585 countsByYear W29902045852021 @default.
- W2990204585 countsByYear W29902045852023 @default.
- W2990204585 crossrefType "journal-article" @default.
- W2990204585 hasAuthorship W2990204585A5003799374 @default.
- W2990204585 hasAuthorship W2990204585A5067310765 @default.
- W2990204585 hasBestOaLocation W29902045851 @default.
- W2990204585 hasConcept C14036430 @default.
- W2990204585 hasConcept C154945302 @default.
- W2990204585 hasConcept C41008148 @default.
- W2990204585 hasConcept C54355233 @default.
- W2990204585 hasConcept C70721500 @default.
- W2990204585 hasConcept C86803240 @default.
- W2990204585 hasConcept C95623464 @default.
- W2990204585 hasConceptScore W2990204585C14036430 @default.
- W2990204585 hasConceptScore W2990204585C154945302 @default.
- W2990204585 hasConceptScore W2990204585C41008148 @default.
- W2990204585 hasConceptScore W2990204585C54355233 @default.
- W2990204585 hasConceptScore W2990204585C70721500 @default.
- W2990204585 hasConceptScore W2990204585C86803240 @default.
- W2990204585 hasConceptScore W2990204585C95623464 @default.
- W2990204585 hasLocation W29902045851 @default.
- W2990204585 hasLocation W29902045852 @default.
- W2990204585 hasOpenAccess W2990204585 @default.
- W2990204585 hasPrimaryLocation W29902045851 @default.
- W2990204585 hasRelatedWork W12701001 @default.
- W2990204585 hasRelatedWork W14373237 @default.
- W2990204585 hasRelatedWork W1507610 @default.
- W2990204585 hasRelatedWork W16713247 @default.
- W2990204585 hasRelatedWork W20182053 @default.
- W2990204585 hasRelatedWork W27321109 @default.
- W2990204585 hasRelatedWork W36700946 @default.
- W2990204585 hasRelatedWork W8231427 @default.
- W2990204585 hasRelatedWork W8288889 @default.
- W2990204585 hasRelatedWork W16826791 @default.
- W2990204585 isParatext "false" @default.
- W2990204585 isRetracted "false" @default.
- W2990204585 magId "2990204585" @default.
- W2990204585 workType "article" @default.