FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990247664> ?p ?o ?g. }

• W2990247664 endingPage "3206" @default.
• W2990247664 startingPage "3196" @default.
• W2990247664 abstract "Androgen deprivation therapy (ADT) is first-line palliative treatment in androgen receptor-positive (AR+) salivary duct carcinoma (SDC), and response rates are 17.6–50.0%. We investigated potential primary ADT resistance mechanisms for their predictive value of clinical benefit from ADT in a cohort of recurrent/metastatic SDC patients receiving palliative ADT (n = 30). We examined mRNA expression of androgen receptor (AR), AR splice variant-7, intratumoral androgen synthesis enzyme-encoding genes AKR1C3, CYP17A1, SRD5A1 and SRD5A2, AR protein expression, ERBB2 (HER2) gene amplification and DNA mutations in driver genes. Furthermore, functional AR pathway activity was determined using a previously reported Bayesian model which infers pathway activity from AR target gene expression levels. SRD5A1 expression levels and AR pathway activity scores were significantly higher in patients with clinical benefit from ADT compared to those without benefit. Survival analysis showed a trend toward a longer median progression-free survival for patients with high SRD5A1 expression levels and high AR pathway activity scores. The AR pathway activity analysis, and not SRD5A1 expression, also showed a trend toward better disease-free survival in an independent cohort of locally advanced SDC patients receiving adjuvant ADT (n = 14) after surgical tumor resection, and in most cases a neck dissection (13/14 patients) and postoperative radiotherapy (13/14 patients). In conclusion, we are the first to describe that AR pathway activity may predict clinical benefit from ADT in SDC patients, but validation in a prospective study is needed." @default.
• W2990247664 created "2019-12-05" @default.
• W2990247664 creator A5006582605 @default.
• W2990247664 creator A5007445651 @default.
• W2990247664 creator A5014312982 @default.
• W2990247664 creator A5021523398 @default.
• W2990247664 creator A5021990817 @default.
• W2990247664 creator A5022010958 @default.
• W2990247664 creator A5024263446 @default.
• W2990247664 creator A5034875458 @default.
• W2990247664 creator A5052480832 @default.
• W2990247664 creator A5060302039 @default.
• W2990247664 creator A5070068818 @default.
• W2990247664 creator A5076046302 @default.
• W2990247664 date "2020-06-01" @default.
• W2990247664 modified "2023-10-16" @default.
• W2990247664 title "Prediction of clinical benefit from androgen deprivation therapy in salivary duct carcinoma patients" @default.
• W2990247664 cites W1548322682 @default.
• W2990247664 cites W1571408166 @default.
• W2990247664 cites W2019607817 @default.
• W2990247664 cites W2032948307 @default.
• W2990247664 cites W2041034966 @default.
• W2990247664 cites W2071417433 @default.
• W2990247664 cites W2077481416 @default.
• W2990247664 cites W2097226696 @default.
• W2990247664 cites W2101979288 @default.
• W2990247664 cites W2143398431 @default.
• W2990247664 cites W2147166694 @default.
• W2990247664 cites W2151317340 @default.
• W2990247664 cites W2336391717 @default.
• W2990247664 cites W2520761147 @default.
• W2990247664 cites W2724491413 @default.
• W2990247664 cites W2739541956 @default.
• W2990247664 cites W2770386076 @default.
• W2990247664 cites W2775239209 @default.
• W2990247664 cites W2791073967 @default.
• W2990247664 cites W2802496767 @default.
• W2990247664 cites W2806209829 @default.
• W2990247664 cites W2892781089 @default.
• W2990247664 cites W2901312960 @default.
• W2990247664 cites W2903176177 @default.
• W2990247664 cites W2912780752 @default.
• W2990247664 cites W2913416111 @default.
• W2990247664 cites W2968726666 @default.
• W2990247664 doi "https://doi.org/10.1002/ijc.32795" @default.
• W2990247664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7187215" @default.
• W2990247664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31745978" @default.
• W2990247664 hasPublicationYear "2020" @default.
• W2990247664 type Work @default.
• W2990247664 sameAs 2990247664 @default.
• W2990247664 citedByCount "24" @default.
• W2990247664 countsByYear W29902476642020 @default.
• W2990247664 countsByYear W29902476642021 @default.
• W2990247664 countsByYear W29902476642022 @default.
• W2990247664 countsByYear W29902476642023 @default.
• W2990247664 crossrefType "journal-article" @default.
• W2990247664 hasAuthorship W2990247664A5006582605 @default.
• W2990247664 hasAuthorship W2990247664A5007445651 @default.
• W2990247664 hasAuthorship W2990247664A5014312982 @default.
• W2990247664 hasAuthorship W2990247664A5021523398 @default.
• W2990247664 hasAuthorship W2990247664A5021990817 @default.
• W2990247664 hasAuthorship W2990247664A5022010958 @default.
• W2990247664 hasAuthorship W2990247664A5024263446 @default.
• W2990247664 hasAuthorship W2990247664A5034875458 @default.
• W2990247664 hasAuthorship W2990247664A5052480832 @default.
• W2990247664 hasAuthorship W2990247664A5060302039 @default.
• W2990247664 hasAuthorship W2990247664A5070068818 @default.
• W2990247664 hasAuthorship W2990247664A5076046302 @default.
• W2990247664 hasBestOaLocation W29902476641 @default.
• W2990247664 hasConcept C104317684 @default.
• W2990247664 hasConcept C121608353 @default.
• W2990247664 hasConcept C126322002 @default.
• W2990247664 hasConcept C134018914 @default.
• W2990247664 hasConcept C142716871 @default.
• W2990247664 hasConcept C143998085 @default.
• W2990247664 hasConcept C2777546739 @default.
• W2990247664 hasConcept C2777899217 @default.
• W2990247664 hasConcept C2777911890 @default.
• W2990247664 hasConcept C2780192828 @default.
• W2990247664 hasConcept C2781066530 @default.
• W2990247664 hasConcept C502942594 @default.
• W2990247664 hasConcept C54355233 @default.
• W2990247664 hasConcept C61367390 @default.
• W2990247664 hasConcept C71315377 @default.
• W2990247664 hasConcept C71924100 @default.
• W2990247664 hasConcept C86803240 @default.
• W2990247664 hasConceptScore W2990247664C104317684 @default.
• W2990247664 hasConceptScore W2990247664C121608353 @default.
• W2990247664 hasConceptScore W2990247664C126322002 @default.
• W2990247664 hasConceptScore W2990247664C134018914 @default.
• W2990247664 hasConceptScore W2990247664C142716871 @default.
• W2990247664 hasConceptScore W2990247664C143998085 @default.
• W2990247664 hasConceptScore W2990247664C2777546739 @default.
• W2990247664 hasConceptScore W2990247664C2777899217 @default.
• W2990247664 hasConceptScore W2990247664C2777911890 @default.
• W2990247664 hasConceptScore W2990247664C2780192828 @default.
• W2990247664 hasConceptScore W2990247664C2781066530 @default.
• W2990247664 hasConceptScore W2990247664C502942594 @default.

• next