FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990253389> ?p ?o ?g. }

• W2990253389 endingPage "312" @default.
• W2990253389 startingPage "267" @default.
• W2990253389 abstract "T cells play a pivotal role in orchestrating immune responses directed against a foreign (allogeneic) graft. For T cells to become fully activated, the T-cell receptor (TCR) must interact with the major histocompatibility complex (MHC) plus peptide complex on antigen-presenting cells (APCs), followed by a second positive costimulatory signal. In the absence of this second signal, T cells become anergic or undergo deletion. By blocking positive costimulatory signaling, T-cell allo-responses can be aborted, thus preventing graft rejection and promoting long-term allograft survival and possibly tolerance (Alegre ML, Najafian N, Curr Mol Med 6:843-857, 2006; Li XC, Rothstein DM, Sayegh MH, Immunol Rev 229:271-293, 2009). In addition, costimulatory molecules can provide negative coinhibitory signals that inhibit T-cell activation and terminate immune responses; strategies to promote these pathways can also lead to graft tolerance (Boenisch O, Sayegh MH, Najafian N, Curr Opin Organ Transplant 13:373-378, 2008). However, T-cell costimulation involves an incredibly complex array of interactions that may act simultaneously or at different times in the immune response and whose relative importance varies depending on the different T-cell subsets and activation status. In transplantation, the presence of foreign alloantigen incites not only destructive T effector cells but also protective regulatory T cells, the balance of which ultimately determines the fate of the allograft (Lechler RI, Garden OA, Turka LA, Nat Rev Immunol 3:147-158, 2003). Since the processes of alloantigen-specific rejection and regulation both require activation of T cells, costimulatory interactions may have opposing or synergistic roles depending on the cell being targeted. Such complexities present both challenges and opportunities in targeting T-cell costimulatory pathways for therapeutic purposes. In this chapter, we summarize our current knowledge of the various costimulatory pathways in transplantation and review the current state and challenges of harnessing these pathways to promote graft tolerance (summarized in Table 10.1)." @default.
• W2990253389 created "2019-12-05" @default.
• W2990253389 creator A5002049878 @default.
• W2990253389 creator A5028211848 @default.
• W2990253389 creator A5084768187 @default.
• W2990253389 date "2019-01-01" @default.
• W2990253389 modified "2023-10-16" @default.
• W2990253389 title "Costimulation Blockade in Transplantation" @default.
• W2990253389 cites W1484194160 @default.
• W2990253389 cites W1485526722 @default.
• W2990253389 cites W1486346820 @default.
• W2990253389 cites W1489663451 @default.
• W2990253389 cites W1493299959 @default.
• W2990253389 cites W1498169316 @default.
• W2990253389 cites W1506819618 @default.
• W2990253389 cites W1513619062 @default.
• W2990253389 cites W1517398753 @default.
• W2990253389 cites W1518371662 @default.
• W2990253389 cites W1519521580 @default.
• W2990253389 cites W1520373882 @default.
• W2990253389 cites W1520683019 @default.
• W2990253389 cites W1521092162 @default.
• W2990253389 cites W1528492996 @default.
• W2990253389 cites W1542262758 @default.
• W2990253389 cites W1544679084 @default.
• W2990253389 cites W1548331405 @default.
• W2990253389 cites W1552195551 @default.
• W2990253389 cites W1555557841 @default.
• W2990253389 cites W1558405203 @default.
• W2990253389 cites W1561537749 @default.
• W2990253389 cites W1581554632 @default.
• W2990253389 cites W1607301590 @default.
• W2990253389 cites W1609716101 @default.
• W2990253389 cites W1626388077 @default.
• W2990253389 cites W1630218117 @default.
• W2990253389 cites W1661441964 @default.
• W2990253389 cites W1665983768 @default.
• W2990253389 cites W1667545291 @default.
• W2990253389 cites W1706798736 @default.
• W2990253389 cites W1738685314 @default.
• W2990253389 cites W1764700682 @default.
• W2990253389 cites W1810044600 @default.
• W2990253389 cites W1830022324 @default.
• W2990253389 cites W1846512082 @default.
• W2990253389 cites W1846571856 @default.
• W2990253389 cites W1862437987 @default.
• W2990253389 cites W1867135851 @default.
• W2990253389 cites W1867838015 @default.
• W2990253389 cites W1888609037 @default.
• W2990253389 cites W1889565933 @default.
• W2990253389 cites W1905064515 @default.
• W2990253389 cites W1913866070 @default.
• W2990253389 cites W1914573154 @default.
• W2990253389 cites W1920762003 @default.
• W2990253389 cites W1930287693 @default.
• W2990253389 cites W1948343798 @default.
• W2990253389 cites W1952399407 @default.
• W2990253389 cites W1965335458 @default.
• W2990253389 cites W1965786965 @default.
• W2990253389 cites W1967710960 @default.
• W2990253389 cites W1968566327 @default.
• W2990253389 cites W1971895216 @default.
• W2990253389 cites W1972073222 @default.
• W2990253389 cites W1972249669 @default.
• W2990253389 cites W1972388670 @default.
• W2990253389 cites W1972640898 @default.
• W2990253389 cites W1973040111 @default.
• W2990253389 cites W1974381902 @default.
• W2990253389 cites W1974532798 @default.
• W2990253389 cites W1975929837 @default.
• W2990253389 cites W1976856036 @default.
• W2990253389 cites W1978224572 @default.
• W2990253389 cites W1979674588 @default.
• W2990253389 cites W1979721491 @default.
• W2990253389 cites W1980719426 @default.
• W2990253389 cites W1981712454 @default.
• W2990253389 cites W1982505108 @default.
• W2990253389 cites W1985092313 @default.
• W2990253389 cites W1986536152 @default.
• W2990253389 cites W1989473696 @default.
• W2990253389 cites W1990429835 @default.
• W2990253389 cites W1991807494 @default.
• W2990253389 cites W1992184534 @default.
• W2990253389 cites W1994478925 @default.
• W2990253389 cites W1996952278 @default.
• W2990253389 cites W1999245418 @default.
• W2990253389 cites W1999843687 @default.
• W2990253389 cites W2001101603 @default.
• W2990253389 cites W2001578637 @default.
• W2990253389 cites W2001868699 @default.
• W2990253389 cites W2002905931 @default.
• W2990253389 cites W2003697485 @default.
• W2990253389 cites W2003896199 @default.
• W2990253389 cites W2006554521 @default.
• W2990253389 cites W2006561389 @default.
• W2990253389 cites W2008367578 @default.
• W2990253389 cites W2009325397 @default.
• W2990253389 cites W2009661102 @default.

• next