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- W2990255718 abstract "Background: Several studies have reported an association between particulate matter and endothelial dysfunction. Only a few studies have examined the impact of air temperature on endothelial function and little is known about the interactions between temperature and particulate matter. Aims: The objective of our analyses was to investigate short-term effects of temperature as well as interactive effects between temperature and particulate matter with an aerodynamic diameter ?2.5 µm (PM2.5) on endothelial function. Methods: Between November 2004 and December 2005 flow-mediated dilatation (FMD), a marker of endothelial dysfunction, was measured using brachial artery ultrasound on four consecutive days in 22 individuals with type-2 diabetes mellitus in Chapel Hill, North Carolina (USA). Daily measurements of meteorological and PM2.5 data were obtained from a central rooftop monitoring site. In order to assess temperature effects and the interaction between temperature and PM2.5 on FMD we used additive mixed models adjusting for time?trend, day of the week, relative humidity and barometric pressure. For analyzing interactive effects, PM2.5 was divided into low (<25%-quartile), medium (25%?74%) and high (?75%?quartile) concentrations. Results: A 1°C decrease in temperature was associated with an immediate (same day) as well as delayed decreases in FMD mean with a delay of one and four days (3.9% (95%?confidence interval:[?6.5;?1.2%])). Increasing PM2.5 concentration strengthened the association between temperature and FMD. Temperature effects on FMD were more pronounced in association with high (-6.3% [?10.7;-1.8%]) PM2.5 concentrations compared to medium (?3.5% [-6.5;-0.4]) concentrations with a delay of four days. Conclusions: We detected an association between a decrement in temperature and decreases in FMD. Moreover, a significant interaction between temperature and PM2.5 on FMD was found. Our findings support the hypothesis that temperature and PM2.5 might have synergistic effects on health outcomes." @default.
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- W2990255718 date "2013-09-19" @default.
- W2990255718 modified "2023-09-26" @default.
- W2990255718 title "Interactive Effects between Air Temperature and PM2.5 on Endothelial Function in Diabetic Individuals" @default.
- W2990255718 doi "https://doi.org/10.1289/isee.2013.o-1-26-05" @default.
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