Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990273274> ?p ?o ?g. }
- W2990273274 abstract "Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyron mutant embryos carrying a null mutation in paf1 were analyzed in detail. In the absence of zygotic paf1 function, definitive premigratory NC progenitors arise but fail to maintain expression of the sox10 specification gene. The mutant NC progenitors migrate aberrantly and fail to differentiate appropriately. Blood and germ cell progenitor development is affected similarly. Development of mutant NC could be rescued by additional loss of positive transcription elongation factor b (P-TEFb) activity, a key factor in promoting transcription elongation. Consistent with the interpretation that inhibiting/delaying expression of some genes is essential for maintaining progenitors, mutant embryos lacking the CDK9 kinase component of P-TEFb exhibit a surfeit of NC progenitors and their derivatives. We propose Paf1C and P-TEFb act antagonistically to regulate the timing of the expression of genes needed for NC development." @default.
- W2990273274 created "2019-12-05" @default.
- W2990273274 creator A5002970460 @default.
- W2990273274 creator A5011997875 @default.
- W2990273274 creator A5012832646 @default.
- W2990273274 creator A5028659798 @default.
- W2990273274 creator A5028760495 @default.
- W2990273274 creator A5033428495 @default.
- W2990273274 creator A5041584553 @default.
- W2990273274 creator A5056271226 @default.
- W2990273274 creator A5066164981 @default.
- W2990273274 creator A5072367040 @default.
- W2990273274 creator A5082727536 @default.
- W2990273274 creator A5086372369 @default.
- W2990273274 date "2019-01-01" @default.
- W2990273274 modified "2023-10-17" @default.
- W2990273274 title "The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors" @default.
- W2990273274 cites W1565566882 @default.
- W2990273274 cites W1571663274 @default.
- W2990273274 cites W1694587304 @default.
- W2990273274 cites W1964932556 @default.
- W2990273274 cites W1986388692 @default.
- W2990273274 cites W1991702744 @default.
- W2990273274 cites W1993604403 @default.
- W2990273274 cites W1996183355 @default.
- W2990273274 cites W1999913971 @default.
- W2990273274 cites W2000948741 @default.
- W2990273274 cites W2002085309 @default.
- W2990273274 cites W2002466559 @default.
- W2990273274 cites W2004823255 @default.
- W2990273274 cites W2011520543 @default.
- W2990273274 cites W2014536457 @default.
- W2990273274 cites W2015068085 @default.
- W2990273274 cites W2017019569 @default.
- W2990273274 cites W2018425216 @default.
- W2990273274 cites W2019721440 @default.
- W2990273274 cites W2023491365 @default.
- W2990273274 cites W2027349141 @default.
- W2990273274 cites W2030197516 @default.
- W2990273274 cites W2032749894 @default.
- W2990273274 cites W2034559511 @default.
- W2990273274 cites W2043298709 @default.
- W2990273274 cites W2043562679 @default.
- W2990273274 cites W2057228860 @default.
- W2990273274 cites W2057887205 @default.
- W2990273274 cites W2064210252 @default.
- W2990273274 cites W2065290728 @default.
- W2990273274 cites W2066665326 @default.
- W2990273274 cites W2068166332 @default.
- W2990273274 cites W2072898686 @default.
- W2990273274 cites W2074459099 @default.
- W2990273274 cites W2078531707 @default.
- W2990273274 cites W2080609747 @default.
- W2990273274 cites W2096251733 @default.
- W2990273274 cites W2097009498 @default.
- W2990273274 cites W2098184015 @default.
- W2990273274 cites W2101835520 @default.
- W2990273274 cites W2104330134 @default.
- W2990273274 cites W2107635128 @default.
- W2990273274 cites W2109504889 @default.
- W2990273274 cites W2110726136 @default.
- W2990273274 cites W2118160713 @default.
- W2990273274 cites W2120703838 @default.
- W2990273274 cites W2125349610 @default.
- W2990273274 cites W2125522271 @default.
- W2990273274 cites W2130124765 @default.
- W2990273274 cites W2134374915 @default.
- W2990273274 cites W2135229538 @default.
- W2990273274 cites W2149799561 @default.
- W2990273274 cites W2151289280 @default.
- W2990273274 cites W2152835473 @default.
- W2990273274 cites W2159733516 @default.
- W2990273274 cites W2160406987 @default.
- W2990273274 cites W2162073604 @default.
- W2990273274 cites W2162800505 @default.
- W2990273274 cites W2166996710 @default.
- W2990273274 cites W2182498448 @default.
- W2990273274 cites W2193525073 @default.
- W2990273274 cites W2250973263 @default.
- W2990273274 cites W2464362331 @default.
- W2990273274 cites W2469370169 @default.
- W2990273274 cites W2513354020 @default.
- W2990273274 cites W2515589436 @default.
- W2990273274 cites W2538304990 @default.
- W2990273274 cites W2553142899 @default.
- W2990273274 cites W2572940016 @default.
- W2990273274 cites W2597057668 @default.
- W2990273274 cites W2598811737 @default.
- W2990273274 cites W2751831226 @default.
- W2990273274 cites W2753497899 @default.
- W2990273274 cites W2765381607 @default.
- W2990273274 cites W2770619281 @default.
- W2990273274 cites W2802479546 @default.
- W2990273274 cites W2888327454 @default.
- W2990273274 cites W2888537731 @default.
- W2990273274 cites W2955819370 @default.
- W2990273274 cites W3022823009 @default.
- W2990273274 doi "https://doi.org/10.1242/dev.180133" @default.
- W2990273274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6955205" @default.
- W2990273274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31784460" @default.