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- W2990280215 endingPage "2822.e5" @default.
- W2990280215 startingPage "2810" @default.
- W2990280215 abstract "Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs undergo rapid 3- to 5-fold expansion during adaptive immune responses, but these ECM-rich structures are not permanently damaged. Whether conduit flow or filtering function is affected during LN expansion is unknown. Here, we show that conduits are partially disrupted during acute LN expansion, but FRC-FRC contacts remain connected. We reveal that polarized FRCs deposit ECM basolaterally using LL5-β and that ECM production is regulated at transcriptional and secretory levels by the C-type lectin CLEC-2, expressed by dendritic cells. Inflamed LNs maintain conduit size exclusion, and flow is disrupted but persists, indicating the robustness of this structure despite rapid tissue expansion. We show how dynamic communication between peripheral tissues and LNs provides a mechanism to prevent inflammation-induced fibrosis in lymphoid tissue." @default.
- W2990280215 created "2019-12-05" @default.
- W2990280215 creator A5009703904 @default.
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- W2990280215 creator A5079825073 @default.
- W2990280215 creator A5091754913 @default.
- W2990280215 date "2019-11-01" @default.
- W2990280215 modified "2023-10-17" @default.
- W2990280215 title "Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion" @default.
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