FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990280800> ?p ?o ?g. }

• W2990280800 endingPage "1909" @default.
• W2990280800 startingPage "1909" @default.
• W2990280800 abstract "Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in activating cellular and humoral immune responses. DC-based tumor vaccines targeting tumor-associated antigens (TAAs) have been extensively tested and demonstrated to be safe and potent in inducing anti-TAA immune responses in cancer patients. Sipuleucel-T (Provenge), a cancer vaccine of autologous DCs loaded with TAA, was approved by the United States Food and Drug Administration (FDA) for the treatment of castration-resistant prostate cancer. Sipuleucel-T prolongs patient survival, but has little or no effect on clinical disease progression or biomarker kinetics. Due to the overall limited clinical efficacy of tumor vaccines, there is a need to enhance their potency. PD-L1 is a key immune checkpoint molecule and is frequently overexpressed on tumor cells to evade antitumor immune destruction. Repeated administrations of PD-L1 or PD-1 antibodies have induced sustained tumor regression in a fraction of cancer patients. In this study, we tested whether vaccinations with DCs, loaded with a PD-L1 immunogen (PDL1-Vax), are able to induce anti-PD-L1 immune responses. We found that DCs loaded with PDL1-Vax induced anti-PD-L1 antibody and T cell responses in immunized mice and that PD-L1-specific CTLs had cytolytic activities against PD-L1+ tumor cells. We demonstrated that vaccination with PDL1-Vax DCs potently inhibited the growth of PD-L1+ tumor cells. In summary, this study demonstrates for the first time the principle and feasibility of DC vaccination (PDL1-Vax) to actively induce anti-PD-L1 antibody and T cell responses capable of inhibiting PD-L1+ tumor growth. This novel anti-PD-L1 vaccination strategy could be used for cancer treatment and prevention." @default.
• W2990280800 created "2019-12-05" @default.
• W2990280800 creator A5010479652 @default.
• W2990280800 creator A5016983759 @default.
• W2990280800 creator A5033533946 @default.
• W2990280800 creator A5039932557 @default.
• W2990280800 creator A5044301848 @default.
• W2990280800 creator A5050211074 @default.
• W2990280800 creator A5051005518 @default.
• W2990280800 creator A5053106966 @default.
• W2990280800 creator A5060055505 @default.
• W2990280800 creator A5064468525 @default.
• W2990280800 date "2019-12-01" @default.
• W2990280800 modified "2023-10-14" @default.
• W2990280800 title "A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention" @default.
• W2990280800 cites W1492054936 @default.
• W2990280800 cites W1565566945 @default.
• W2990280800 cites W1577612079 @default.
• W2990280800 cites W1602824038 @default.
• W2990280800 cites W1661544713 @default.
• W2990280800 cites W1862569453 @default.
• W2990280800 cites W1901785997 @default.
• W2990280800 cites W1925817305 @default.
• W2990280800 cites W1966408842 @default.
• W2990280800 cites W1972189666 @default.
• W2990280800 cites W1982787945 @default.
• W2990280800 cites W1986097339 @default.
• W2990280800 cites W1989673842 @default.
• W2990280800 cites W1993247953 @default.
• W2990280800 cites W1993453917 @default.
• W2990280800 cites W1994551000 @default.
• W2990280800 cites W2004150448 @default.
• W2990280800 cites W2010121426 @default.
• W2990280800 cites W2016983859 @default.
• W2990280800 cites W2020361749 @default.
• W2990280800 cites W2025436792 @default.
• W2990280800 cites W2028575270 @default.
• W2990280800 cites W2044789025 @default.
• W2990280800 cites W2045066389 @default.
• W2990280800 cites W2052727153 @default.
• W2990280800 cites W2055868508 @default.
• W2990280800 cites W2058088785 @default.
• W2990280800 cites W2062254683 @default.
• W2990280800 cites W2065554630 @default.
• W2990280800 cites W2076361525 @default.
• W2990280800 cites W2078393591 @default.
• W2990280800 cites W2079315541 @default.
• W2990280800 cites W2079361633 @default.
• W2990280800 cites W2089187782 @default.
• W2990280800 cites W2094426046 @default.
• W2990280800 cites W2095129122 @default.
• W2990280800 cites W2098062162 @default.
• W2990280800 cites W2101653483 @default.
• W2990280800 cites W2104750134 @default.
• W2990280800 cites W2105607314 @default.
• W2990280800 cites W2118111782 @default.
• W2990280800 cites W2121475848 @default.
• W2990280800 cites W2125566625 @default.
• W2990280800 cites W2126043466 @default.
• W2990280800 cites W2126972494 @default.
• W2990280800 cites W2130867278 @default.
• W2990280800 cites W2133294507 @default.
• W2990280800 cites W2135912626 @default.
• W2990280800 cites W2136590857 @default.
• W2990280800 cites W2138706726 @default.
• W2990280800 cites W2141649011 @default.
• W2990280800 cites W2146436127 @default.
• W2990280800 cites W2156383220 @default.
• W2990280800 cites W2157017096 @default.
• W2990280800 cites W2172160382 @default.
• W2990280800 cites W2209812019 @default.
• W2990280800 cites W2257916459 @default.
• W2990280800 cites W2528386527 @default.
• W2990280800 cites W2787663719 @default.
• W2990280800 cites W2804079188 @default.
• W2990280800 cites W2805359783 @default.
• W2990280800 cites W2936551248 @default.
• W2990280800 cites W2954157188 @default.
• W2990280800 cites W4238423864 @default.
• W2990280800 cites W4249736906 @default.
• W2990280800 doi "https://doi.org/10.3390/cancers11121909" @default.
• W2990280800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966557" @default.
• W2990280800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31805690" @default.
• W2990280800 hasPublicationYear "2019" @default.
• W2990280800 type Work @default.
• W2990280800 sameAs 2990280800 @default.
• W2990280800 citedByCount "10" @default.
• W2990280800 countsByYear W29902808002020 @default.
• W2990280800 countsByYear W29902808002021 @default.
• W2990280800 countsByYear W29902808002022 @default.
• W2990280800 countsByYear W29902808002023 @default.
• W2990280800 crossrefType "journal-article" @default.
• W2990280800 hasAuthorship W2990280800A5010479652 @default.
• W2990280800 hasAuthorship W2990280800A5016983759 @default.
• W2990280800 hasAuthorship W2990280800A5033533946 @default.
• W2990280800 hasAuthorship W2990280800A5039932557 @default.
• W2990280800 hasAuthorship W2990280800A5044301848 @default.
• W2990280800 hasAuthorship W2990280800A5050211074 @default.

• next