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• W2990321742 abstract "Abstract Over the past decade, there has been a massive scale-up of primary and secondary prevention services to reduce the population-wide incidence of HIV. However, the impact of these services on HIV incidence has not been demonstrated using a prospectively followed, population-based cohort from South Africa—the country with the world’s highest rate of new infections. To quantify HIV incidence trends in a hyperendemic population, we tested a cohort of 22,239 uninfected participants over 92,877 person-years of observation. We report a 43% decline in the overall incidence rate between 2012 and 2017, from 4.0 to 2.3 seroconversion events per 100 person-years. Men experienced an earlier and larger incidence decline than women (59% vs. 37% reduction), which is consistent with male circumcision scale-up and higher levels of female antiretroviral therapy coverage. Additional efforts are needed to get more men onto consistent, suppressive treatment so that new HIV infections can be reduced among women." @default.
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• W2990321742 date "2019-12-02" @default.
• W2990321742 modified "2023-10-18" @default.
• W2990321742 title "Declines in HIV incidence among men and women in a South African population-based cohort" @default.
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• W2990321742 doi "https://doi.org/10.1038/s41467-019-13473-y" @default.
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