Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990326583> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2990326583 abstract "Cardiovascular and renal diseases are one of the main health problems in all industrialized countries. Their incidence is constantly increasing due to the aging of the population and the greater prevalence of obesity and type 2 diabetes. Clinical evidence suggests that aldosterone and the activation of mineralocorticoid receptors (MR) have a role in the pathophysiology of cardiovascular and renal diseases. Moreover, clinical studies demonstrate the benefits of mineralocorticoid receptor antagonists (MRAs) on mortality and progression of heart and kidney disease. In addition to renal effects on body fluid homeostasis, aldosterone has multiple extrarenal effects including the induction of inflammation, vascular rigidity, collagen formation and stimulation of fibrosis. Given the fundamental role of MR activation in renal and cardiac fibrosis, effective and selective blocking of the signal with MRAs can be used in the clinical practice to prevent or slow down the progression of heart and kidney diseases. The aim of the present work is to review the role of MRAs in light of the new evidence as well as its potential use as an antifibrotic in chronic kidney disease (CKD). The initial clinical results suggest that MRAs are potentially useful in treating patients with chronic kidney disease, particularly in cases of diabetic nephropathy. We don't yet have efficacy and safety data on the progression of kidney disease up to the end stage (ESRD) and filling this gap represents an important target for future trials." @default.
- W2990326583 created "2019-12-05" @default.
- W2990326583 creator A5017431606 @default.
- W2990326583 creator A5018790889 @default.
- W2990326583 creator A5048712162 @default.
- W2990326583 creator A5082194244 @default.
- W2990326583 creator A5087811410 @default.
- W2990326583 creator A5088416548 @default.
- W2990326583 creator A5091280594 @default.
- W2990326583 date "2019-07-24" @default.
- W2990326583 modified "2023-09-23" @default.
- W2990326583 title "Antifibrotic renal role of mineralcorticoid receptor antagonists" @default.
- W2990326583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31373464" @default.
- W2990326583 hasPublicationYear "2019" @default.
- W2990326583 type Work @default.
- W2990326583 sameAs 2990326583 @default.
- W2990326583 citedByCount "2" @default.
- W2990326583 countsByYear W29903265832022 @default.
- W2990326583 crossrefType "journal-article" @default.
- W2990326583 hasAuthorship W2990326583A5017431606 @default.
- W2990326583 hasAuthorship W2990326583A5018790889 @default.
- W2990326583 hasAuthorship W2990326583A5048712162 @default.
- W2990326583 hasAuthorship W2990326583A5082194244 @default.
- W2990326583 hasAuthorship W2990326583A5087811410 @default.
- W2990326583 hasAuthorship W2990326583A5088416548 @default.
- W2990326583 hasAuthorship W2990326583A5091280594 @default.
- W2990326583 hasConcept C126322002 @default.
- W2990326583 hasConcept C134018914 @default.
- W2990326583 hasConcept C189135053 @default.
- W2990326583 hasConcept C2778525890 @default.
- W2990326583 hasConcept C2778653478 @default.
- W2990326583 hasConcept C2780072264 @default.
- W2990326583 hasConcept C2780091579 @default.
- W2990326583 hasConcept C2780559512 @default.
- W2990326583 hasConcept C2908647359 @default.
- W2990326583 hasConcept C71924100 @default.
- W2990326583 hasConcept C99454951 @default.
- W2990326583 hasConceptScore W2990326583C126322002 @default.
- W2990326583 hasConceptScore W2990326583C134018914 @default.
- W2990326583 hasConceptScore W2990326583C189135053 @default.
- W2990326583 hasConceptScore W2990326583C2778525890 @default.
- W2990326583 hasConceptScore W2990326583C2778653478 @default.
- W2990326583 hasConceptScore W2990326583C2780072264 @default.
- W2990326583 hasConceptScore W2990326583C2780091579 @default.
- W2990326583 hasConceptScore W2990326583C2780559512 @default.
- W2990326583 hasConceptScore W2990326583C2908647359 @default.
- W2990326583 hasConceptScore W2990326583C71924100 @default.
- W2990326583 hasConceptScore W2990326583C99454951 @default.
- W2990326583 hasIssue "4" @default.
- W2990326583 hasOpenAccess W2990326583 @default.
- W2990326583 hasRelatedWork W2026181645 @default.
- W2990326583 hasRelatedWork W2041864236 @default.
- W2990326583 hasRelatedWork W2168712739 @default.
- W2990326583 hasRelatedWork W2330523890 @default.
- W2990326583 hasRelatedWork W2398725298 @default.
- W2990326583 hasRelatedWork W2602540541 @default.
- W2990326583 hasRelatedWork W2890860459 @default.
- W2990326583 hasRelatedWork W2921544138 @default.
- W2990326583 hasRelatedWork W2937297943 @default.
- W2990326583 hasRelatedWork W2980222771 @default.
- W2990326583 hasRelatedWork W3010478612 @default.
- W2990326583 hasRelatedWork W3016166114 @default.
- W2990326583 hasRelatedWork W3103097801 @default.
- W2990326583 hasRelatedWork W3104991255 @default.
- W2990326583 hasRelatedWork W3154796033 @default.
- W2990326583 hasRelatedWork W3157024686 @default.
- W2990326583 hasRelatedWork W3208249205 @default.
- W2990326583 hasRelatedWork W3211790489 @default.
- W2990326583 hasRelatedWork W3212126026 @default.
- W2990326583 hasRelatedWork W987487382 @default.
- W2990326583 hasVolume "36" @default.
- W2990326583 isParatext "false" @default.
- W2990326583 isRetracted "false" @default.
- W2990326583 magId "2990326583" @default.
- W2990326583 workType "article" @default.