FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990363727> ?p ?o ?g. }

• W2990363727 abstract "Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca2+ concentration through a dysfunction of T-type Ca2+ channels. Thus, T-type calcium channels could be a target in drug discovery for the treatments of neuropathic pain and epilepsy. From rational drug design approach, a group of 2,5-disubstituted 1,3,4-oxadiazole molecules was synthesized and their selective T-type channel inhibitions were evaluated. The synthetic strategy consists of a short sequence of three reactions: (i) condensation of thiosemicarbazide with acid chlorides; (ii) ring closing by 1,3-dibromo-5,5- dimethylhydantoin; and (iii) coupling with various acid chlorides. 5-Chloro-N-(5- phenyl-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide (11) was found to selectively inhibit T-type Ca2+ channel over Na+ and K+ channels in mouse dorsal root ganglion neurons and/or human embryonic kidney (HEK)-293 cells and to suppress seizure-induced death in mouse model. Consequently, compound 11 is a useful probe for investigation of physiologic and pathophysiologic roles of the T-channel, and provides a basis to develop a novel therapeutic to treat chronic neuropathic and inflammatory pains." @default.
• W2990363727 created "2019-12-05" @default.
• W2990363727 creator A5000899288 @default.
• W2990363727 creator A5003769105 @default.
• W2990363727 creator A5009496335 @default.
• W2990363727 creator A5013004807 @default.
• W2990363727 creator A5022248804 @default.
• W2990363727 creator A5024578634 @default.
• W2990363727 creator A5031214338 @default.
• W2990363727 creator A5047871046 @default.
• W2990363727 creator A5052054550 @default.
• W2990363727 creator A5069938818 @default.
• W2990363727 creator A5080911765 @default.
• W2990363727 date "2020-01-01" @default.
• W2990363727 modified "2023-10-16" @default.
• W2990363727 title "Synthesis of 1,3,4-Oxadiazoles as Selective T-Type Calcium Channel Inhibitors" @default.
• W2990363727 cites W1573456797 @default.
• W2990363727 cites W1610976729 @default.
• W2990363727 cites W1616459298 @default.
• W2990363727 cites W1845250825 @default.
• W2990363727 cites W1964092556 @default.
• W2990363727 cites W1974758589 @default.
• W2990363727 cites W1975189782 @default.
• W2990363727 cites W1978379264 @default.
• W2990363727 cites W1983267597 @default.
• W2990363727 cites W1985788857 @default.
• W2990363727 cites W1994424364 @default.
• W2990363727 cites W1999515062 @default.
• W2990363727 cites W2001427640 @default.
• W2990363727 cites W2002331174 @default.
• W2990363727 cites W2009388059 @default.
• W2990363727 cites W2023213460 @default.
• W2990363727 cites W2025354712 @default.
• W2990363727 cites W2026735406 @default.
• W2990363727 cites W2028216578 @default.
• W2990363727 cites W2036985062 @default.
• W2990363727 cites W2082470387 @default.
• W2990363727 cites W2096701787 @default.
• W2990363727 cites W2100906077 @default.
• W2990363727 cites W2114561675 @default.
• W2990363727 cites W2117496744 @default.
• W2990363727 cites W2124467099 @default.
• W2990363727 cites W2133819402 @default.
• W2990363727 cites W2144365512 @default.
• W2990363727 cites W2159332152 @default.
• W2990363727 cites W2340307318 @default.
• W2990363727 doi "https://doi.org/10.3987/com-19-s(f)5" @default.
• W2990363727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7413294" @default.
• W2990363727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32773946" @default.
• W2990363727 hasPublicationYear "2020" @default.
• W2990363727 type Work @default.
• W2990363727 sameAs 2990363727 @default.
• W2990363727 citedByCount "2" @default.
• W2990363727 countsByYear W29903637272021 @default.
• W2990363727 countsByYear W29903637272023 @default.
• W2990363727 crossrefType "journal-article" @default.
• W2990363727 hasAuthorship W2990363727A5000899288 @default.
• W2990363727 hasAuthorship W2990363727A5003769105 @default.
• W2990363727 hasAuthorship W2990363727A5009496335 @default.
• W2990363727 hasAuthorship W2990363727A5013004807 @default.
• W2990363727 hasAuthorship W2990363727A5022248804 @default.
• W2990363727 hasAuthorship W2990363727A5024578634 @default.
• W2990363727 hasAuthorship W2990363727A5031214338 @default.
• W2990363727 hasAuthorship W2990363727A5047871046 @default.
• W2990363727 hasAuthorship W2990363727A5052054550 @default.
• W2990363727 hasAuthorship W2990363727A5069938818 @default.
• W2990363727 hasAuthorship W2990363727A5080911765 @default.
• W2990363727 hasBestOaLocation W29903637272 @default.
• W2990363727 hasConcept C15744967 @default.
• W2990363727 hasConcept C169760540 @default.
• W2990363727 hasConcept C170493617 @default.
• W2990363727 hasConcept C174510640 @default.
• W2990363727 hasConcept C178790620 @default.
• W2990363727 hasConcept C181080969 @default.
• W2990363727 hasConcept C185592680 @default.
• W2990363727 hasConcept C18699975 @default.
• W2990363727 hasConcept C2776281502 @default.
• W2990363727 hasConcept C2777107010 @default.
• W2990363727 hasConcept C2778186239 @default.
• W2990363727 hasConcept C2779491297 @default.
• W2990363727 hasConcept C29730261 @default.
• W2990363727 hasConcept C30979828 @default.
• W2990363727 hasConcept C519063684 @default.
• W2990363727 hasConcept C55493867 @default.
• W2990363727 hasConcept C71240020 @default.
• W2990363727 hasConcept C71924100 @default.
• W2990363727 hasConcept C79879829 @default.
• W2990363727 hasConcept C85520022 @default.
• W2990363727 hasConcept C94487597 @default.
• W2990363727 hasConcept C98274493 @default.
• W2990363727 hasConceptScore W2990363727C15744967 @default.
• W2990363727 hasConceptScore W2990363727C169760540 @default.
• W2990363727 hasConceptScore W2990363727C170493617 @default.
• W2990363727 hasConceptScore W2990363727C174510640 @default.
• W2990363727 hasConceptScore W2990363727C178790620 @default.
• W2990363727 hasConceptScore W2990363727C181080969 @default.
• W2990363727 hasConceptScore W2990363727C185592680 @default.
• W2990363727 hasConceptScore W2990363727C18699975 @default.
• W2990363727 hasConceptScore W2990363727C2776281502 @default.
• W2990363727 hasConceptScore W2990363727C2777107010 @default.

• next