FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990366068> ?p ?o ?g. }

• W2990366068 endingPage "213" @default.
• W2990366068 startingPage "212" @default.
• W2990366068 abstract "We thank Ning and colleagues for their question on the relationship of pain duration to the effects of vertebroplasty, in relationship to our article.1 In response, we refer the authors to the updated Cochrane review,2 an individual patient data meta-analysis including two placebo-controlled trials,3 and our response to a previous letter,4 which provides comprehensive answers to their queries. The Cochrane review includes a detailed description and potential risk of bias of each of the trials included in the evidence synthesis that formed the basis of our conclusions about the value of vertebroplasty for treatment of painful osteoporotic vertebral fractures.2 Three of the five placebo-controlled trials included in the review only included acute fractures, which was defined variously as pain duration of <6 weeks in the VAPOUR trial, ≤8 weeks,5 and <9 weeks.6 Although the other two trials included some participants with longer symptom duration (mean duration 9 to 9.5 weeks in Buchbinder and colleagues,7 and 16 to 20 weeks in Kallmes and colleagues8), the individual patient data meta-analysis clearly reports that 40% and 20% of participants in the Australian and US trials, respectively, had symptoms for ≤6 weeks.3 The Cochrane review found that overall, based upon high-quality to moderate-quality evidence from five placebo-controlled trials (541 randomized participants), vertebroplasty has no important benefit over placebo in terms of pain, disability, quality of life, or treatment success in the treatment of acute or subacute osteoporotic vertebral fractures.2 A subgroup analysis found that these results were consistent irrespective of average duration of pain, indicating that symptom duration is not a treatment-effect modifier. For example, based upon five trials with 378 participants with acute symptoms (including data from all three trials with only participants with acute fractures, and participants with symptoms for 6 weeks or less from the other two trials), the mean difference in pain at 1 month was –0.25 (95% CI, –0.47 to –0.04) on a 0 to 10 scale, a difference that is clinically unimportant. The corresponding mean difference in pain at 1 month in the participants with fractures for >6 weeks from the Australian and US trials (142 participants) was similarly clinically unimportant (–0.14; 95% CI, –0.47 to 0.19). The test for subgroup differences indicated these results were not different (χ2 = 0.33; degree of freedom [df] = 1; p = 0.57; I2 = 0%). Including only participants with pain defined as having been present for ≤6 weeks (thereby excluding data from both Hansen5 and Firanescu and colleagues6), did not alter these findings. These data are also consistent with the adequately powered subgroup analysis of the individual patient data meta-analysis of the Australian and US trials, which also failed to find a benefit of vertebroplasty over placebo for participants with recent onset fractures.3 Between-group differences in mean change scores at 1 month for pain on a 0 to 10 pain scale was 0.1 (95% CI, –1.4 to 1.6), and for disability, measured on a 0 to 23 modified Roland Morris disability questionnaire, was 0.2 (95% CI, –3.0 to 3.4). We therefore continue to stand by our conclusions that vertebroplasty provides no benefit over placebo for osteoporotic vertebral fractures irrespective of symptom duration." @default.
• W2990366068 created "2019-12-05" @default.
• W2990366068 creator A5004535787 @default.
• W2990366068 creator A5014041200 @default.
• W2990366068 creator A5021940540 @default.
• W2990366068 creator A5032638450 @default.
• W2990366068 creator A5036470851 @default.
• W2990366068 creator A5040569546 @default.
• W2990366068 creator A5042414719 @default.
• W2990366068 creator A5058775754 @default.
• W2990366068 creator A5062883725 @default.
• W2990366068 creator A5064307236 @default.
• W2990366068 creator A5066827451 @default.
• W2990366068 creator A5076667369 @default.
• W2990366068 creator A5082230232 @default.
• W2990366068 creator A5087726384 @default.
• W2990366068 creator A5090296288 @default.
• W2990366068 date "2019-11-19" @default.
• W2990366068 modified "2023-09-27" @default.
• W2990366068 title "Response to: Some Questions About the Article “The Efficacy and Safety of Vertebral Augmentation: A Second ASBMR Task Force Report”" @default.
• W2990366068 cites W2059724197 @default.
• W2990366068 cites W2085293851 @default.
• W2990366068 cites W2115574045 @default.
• W2990366068 cites W2912308276 @default.
• W2990366068 cites W2947696504 @default.
• W2990366068 doi "https://doi.org/10.1002/jbmr.3906" @default.
• W2990366068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31743502" @default.
• W2990366068 hasPublicationYear "2019" @default.
• W2990366068 type Work @default.
• W2990366068 sameAs 2990366068 @default.
• W2990366068 citedByCount "0" @default.
• W2990366068 crossrefType "journal-article" @default.
• W2990366068 hasAuthorship W2990366068A5004535787 @default.
• W2990366068 hasAuthorship W2990366068A5014041200 @default.
• W2990366068 hasAuthorship W2990366068A5021940540 @default.
• W2990366068 hasAuthorship W2990366068A5032638450 @default.
• W2990366068 hasAuthorship W2990366068A5036470851 @default.
• W2990366068 hasAuthorship W2990366068A5040569546 @default.
• W2990366068 hasAuthorship W2990366068A5042414719 @default.
• W2990366068 hasAuthorship W2990366068A5058775754 @default.
• W2990366068 hasAuthorship W2990366068A5062883725 @default.
• W2990366068 hasAuthorship W2990366068A5064307236 @default.
• W2990366068 hasAuthorship W2990366068A5066827451 @default.
• W2990366068 hasAuthorship W2990366068A5076667369 @default.
• W2990366068 hasAuthorship W2990366068A5082230232 @default.
• W2990366068 hasAuthorship W2990366068A5087726384 @default.
• W2990366068 hasAuthorship W2990366068A5090296288 @default.
• W2990366068 hasBestOaLocation W29903660681 @default.
• W2990366068 hasConcept C126322002 @default.
• W2990366068 hasConcept C141071460 @default.
• W2990366068 hasConcept C142724271 @default.
• W2990366068 hasConcept C168563851 @default.
• W2990366068 hasConcept C17744445 @default.
• W2990366068 hasConcept C1862650 @default.
• W2990366068 hasConcept C189708586 @default.
• W2990366068 hasConcept C199539241 @default.
• W2990366068 hasConcept C204787440 @default.
• W2990366068 hasConcept C27081682 @default.
• W2990366068 hasConcept C2779473830 @default.
• W2990366068 hasConcept C535046627 @default.
• W2990366068 hasConcept C71924100 @default.
• W2990366068 hasConcept C95190672 @default.
• W2990366068 hasConceptScore W2990366068C126322002 @default.
• W2990366068 hasConceptScore W2990366068C141071460 @default.
• W2990366068 hasConceptScore W2990366068C142724271 @default.
• W2990366068 hasConceptScore W2990366068C168563851 @default.
• W2990366068 hasConceptScore W2990366068C17744445 @default.
• W2990366068 hasConceptScore W2990366068C1862650 @default.
• W2990366068 hasConceptScore W2990366068C189708586 @default.
• W2990366068 hasConceptScore W2990366068C199539241 @default.
• W2990366068 hasConceptScore W2990366068C204787440 @default.
• W2990366068 hasConceptScore W2990366068C27081682 @default.
• W2990366068 hasConceptScore W2990366068C2779473830 @default.
• W2990366068 hasConceptScore W2990366068C535046627 @default.
• W2990366068 hasConceptScore W2990366068C71924100 @default.
• W2990366068 hasConceptScore W2990366068C95190672 @default.
• W2990366068 hasIssue "1" @default.
• W2990366068 hasLocation W29903660681 @default.
• W2990366068 hasOpenAccess W2990366068 @default.
• W2990366068 hasPrimaryLocation W29903660681 @default.
• W2990366068 hasRelatedWork W1967911880 @default.
• W2990366068 hasRelatedWork W2066421181 @default.
• W2990366068 hasRelatedWork W2073138496 @default.
• W2990366068 hasRelatedWork W2089933404 @default.
• W2990366068 hasRelatedWork W2098995101 @default.
• W2990366068 hasRelatedWork W2181724637 @default.
• W2990366068 hasRelatedWork W2550419422 @default.
• W2990366068 hasRelatedWork W4285503101 @default.
• W2990366068 hasRelatedWork W4304775918 @default.
• W2990366068 hasRelatedWork W4309673403 @default.
• W2990366068 hasVolume "35" @default.
• W2990366068 isParatext "false" @default.
• W2990366068 isRetracted "false" @default.
• W2990366068 magId "2990366068" @default.
• W2990366068 workType "article" @default.