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- W2990420937 abstract "Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. Clinically, drugs are usually used to suppress pain, such as (lidocaine, morphine, etc.), but the effect is short-lived, poor analgesia, and there are certain dependence and side effects. Therefore, the investigation of the treatment of NPP has become an urgent problem in medical, attracting a lot of research attention. P2X7 is dependent on Adenosine triphosphate (ATP) ion channel receptors and has dual functions for the development of nerve damage and pain. In this review, we explored the link between the P2X7 receptor (P2X7R) and NPP, providing insight into the P2X7R and NPP, discussing the pathological mechanism of P2 X7R in NPP and the biological characteristics of P2X7R antagonist inhibiting its over-expression for the targeted therapy of NPP." @default.
- W2990420937 created "2019-12-05" @default.
- W2990420937 creator A5048693191 @default.
- W2990420937 creator A5071091724 @default.
- W2990420937 creator A5081117163 @default.
- W2990420937 date "2020-02-01" @default.
- W2990420937 modified "2023-10-13" @default.
- W2990420937 title "The role and pharmacological properties of the P2X7 receptor in neuropathic pain" @default.
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