Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990439685> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2990439685 endingPage "5030" @default.
- W2990439685 startingPage "5030" @default.
- W2990439685 abstract "Background: Developmental toxicity of perfluoroalkyl substances (PFASs) has been proven in animal studies. This raises concern over the potential effects of PFAS on human reproductive health. However, results of epidemiologic studies of exposed populations are inconsistent.As reported earlier, more than 4 million residents in several areas of North-Rhine Westphalia (NRW), Germany, have been exposed to PFASs in drinking water. PFASs' concentrations in drinking water were used as a surrogate marker of exposure. Aim: Two statistical approaches (linear regression, spatial Bayesian method) are compared to evaluate the association between mother's exposure to PFASs via drinking water and birth outcome in NRW, Germany. Methods PFASs' drinking water concentrations were derived from an extensive monitoring programme of the North Rhine-Westphalia State Environment Agency. Birth outcome was assessed on the basis of the quality control datasets of the respective Medical Association. For a spatially correlated effect, Markov random field (MRF) priors were chosen, which reflect spatial neighborhood relationships. To estimate the posterior inference the Integrated Nested Laplace Approximation (INLA) was used. Results Drinking water analyses from 33892 measurements provided PFOA-concentrations for 260 water supply areas. PFOA-concentrations ranged from below LOQ to 650 ng/l (37 % > LOQ). Birth outcome, maternal smoking status, medication and other confounders were derived on postcode level for 1,176,488 newborns and their mothers between 2003 and 2010.Matching of birth outcome and PFASs' exposure data was successfully achieved by geoprocessing methods in 382 postcode areas, resulting in a total of 281,019 datasets. Strength of effects and potential confounders will be compared. Conclusion Spatial models might account better for the surrogate drinking water contamination, although MRFs only consider confounders on an aggregate basis. Data will be followed on a longitudinal basis." @default.
- W2990439685 created "2019-12-05" @default.
- W2990439685 creator A5006256305 @default.
- W2990439685 creator A5007673880 @default.
- W2990439685 creator A5063131771 @default.
- W2990439685 creator A5063815245 @default.
- W2990439685 creator A5064991508 @default.
- W2990439685 creator A5080129940 @default.
- W2990439685 date "2013-09-19" @default.
- W2990439685 modified "2023-09-23" @default.
- W2990439685 title "Statistical approaches to evaluating the association between mother's exposure to perfluoroalkyl substances (PFASs) and birth outcome in North-Rhine Westphalia" @default.
- W2990439685 doi "https://doi.org/10.1289/isee.2013.p-2-14-01" @default.
- W2990439685 hasPublicationYear "2013" @default.
- W2990439685 type Work @default.
- W2990439685 sameAs 2990439685 @default.
- W2990439685 citedByCount "0" @default.
- W2990439685 crossrefType "journal-article" @default.
- W2990439685 hasAuthorship W2990439685A5006256305 @default.
- W2990439685 hasAuthorship W2990439685A5007673880 @default.
- W2990439685 hasAuthorship W2990439685A5063131771 @default.
- W2990439685 hasAuthorship W2990439685A5063815245 @default.
- W2990439685 hasAuthorship W2990439685A5064991508 @default.
- W2990439685 hasAuthorship W2990439685A5080129940 @default.
- W2990439685 hasConcept C126322002 @default.
- W2990439685 hasConcept C144024400 @default.
- W2990439685 hasConcept C149923435 @default.
- W2990439685 hasConcept C71924100 @default.
- W2990439685 hasConcept C77350462 @default.
- W2990439685 hasConcept C99454951 @default.
- W2990439685 hasConceptScore W2990439685C126322002 @default.
- W2990439685 hasConceptScore W2990439685C144024400 @default.
- W2990439685 hasConceptScore W2990439685C149923435 @default.
- W2990439685 hasConceptScore W2990439685C71924100 @default.
- W2990439685 hasConceptScore W2990439685C77350462 @default.
- W2990439685 hasConceptScore W2990439685C99454951 @default.
- W2990439685 hasIssue "1" @default.
- W2990439685 hasLocation W29904396851 @default.
- W2990439685 hasOpenAccess W2990439685 @default.
- W2990439685 hasPrimaryLocation W29904396851 @default.
- W2990439685 hasRelatedWork W1777541838 @default.
- W2990439685 hasRelatedWork W1961698093 @default.
- W2990439685 hasRelatedWork W2011895691 @default.
- W2990439685 hasRelatedWork W2065302287 @default.
- W2990439685 hasRelatedWork W2088591369 @default.
- W2990439685 hasRelatedWork W2123464811 @default.
- W2990439685 hasRelatedWork W2441989036 @default.
- W2990439685 hasRelatedWork W3029422704 @default.
- W2990439685 hasRelatedWork W4232591746 @default.
- W2990439685 hasRelatedWork W4296552630 @default.
- W2990439685 hasVolume "2013" @default.
- W2990439685 isParatext "false" @default.
- W2990439685 isRetracted "false" @default.
- W2990439685 magId "2990439685" @default.
- W2990439685 workType "article" @default.