Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990456143> ?p ?o ?g. }
- W2990456143 endingPage "23" @default.
- W2990456143 startingPage "1" @default.
- W2990456143 abstract "The aim of this study was to improve the solubility of amiodarone hydrochloride (AMD) and the drug release using its inclusion complexes with 2-hydroxypropyl- β -cyclodextrin (HP- β -CD). The inclusion complexes were prepared by coprecipitation and freeze-drying. The solubility enhancement of AMD/HP- β -CD inclusion complexes by 4–22 times was evaluated by the phase solubility method. The inclusion complexes were studied both in solution and in solid state by spectroscopic methods, dynamic light scattering (DLS) and zeta potential analysis, SEM, and DSC. The formulations of AMD/HP- β -CD inclusion complexes both as powdered form and as matrix tablets showed superior pharmacokinetic performance in improving loading and release properties in respect of those of the insoluble AMD drug. In vitro kinetic study reveals a complex mechanism of release occurring in three steps: the first one being attributed to a burst effect and the other two to different bonding existing in inclusion complexes. An in vivo test on matrix tablets containing Kollidon® and chitosan also reveals a multiple (at least two) peaks release diagram because of both structures of the inclusion complexes and also of different sites of absorption in biological media (digestive tract)." @default.
- W2990456143 created "2019-12-05" @default.
- W2990456143 creator A5026947736 @default.
- W2990456143 creator A5028295433 @default.
- W2990456143 creator A5035347230 @default.
- W2990456143 creator A5047699193 @default.
- W2990456143 creator A5047737345 @default.
- W2990456143 creator A5055987122 @default.
- W2990456143 creator A5058806588 @default.
- W2990456143 creator A5060512022 @default.
- W2990456143 date "2019-11-28" @default.
- W2990456143 modified "2023-10-18" @default.
- W2990456143 title "Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-<i>β</i>-cyclodextrin for Oral Administration of Amiodarone" @default.
- W2990456143 cites W104425861 @default.
- W2990456143 cites W1965122895 @default.
- W2990456143 cites W1965872705 @default.
- W2990456143 cites W1967206987 @default.
- W2990456143 cites W1972455476 @default.
- W2990456143 cites W1973599018 @default.
- W2990456143 cites W1975609947 @default.
- W2990456143 cites W1980233139 @default.
- W2990456143 cites W1981043362 @default.
- W2990456143 cites W1983541140 @default.
- W2990456143 cites W1986931602 @default.
- W2990456143 cites W1989511197 @default.
- W2990456143 cites W1990847867 @default.
- W2990456143 cites W2000092715 @default.
- W2990456143 cites W2004844617 @default.
- W2990456143 cites W2007697051 @default.
- W2990456143 cites W2011671192 @default.
- W2990456143 cites W2015639279 @default.
- W2990456143 cites W2022488910 @default.
- W2990456143 cites W2023655173 @default.
- W2990456143 cites W2024061701 @default.
- W2990456143 cites W2027948774 @default.
- W2990456143 cites W2043177436 @default.
- W2990456143 cites W2046636459 @default.
- W2990456143 cites W2052446737 @default.
- W2990456143 cites W2054800049 @default.
- W2990456143 cites W2056882013 @default.
- W2990456143 cites W2056926950 @default.
- W2990456143 cites W2058699044 @default.
- W2990456143 cites W2062079439 @default.
- W2990456143 cites W2062693459 @default.
- W2990456143 cites W2064735871 @default.
- W2990456143 cites W2070094522 @default.
- W2990456143 cites W2073394985 @default.
- W2990456143 cites W2073909843 @default.
- W2990456143 cites W2079737808 @default.
- W2990456143 cites W2080077405 @default.
- W2990456143 cites W2081322087 @default.
- W2990456143 cites W2082697065 @default.
- W2990456143 cites W2094153855 @default.
- W2990456143 cites W2095238868 @default.
- W2990456143 cites W2134205677 @default.
- W2990456143 cites W2134267380 @default.
- W2990456143 cites W2148343657 @default.
- W2990456143 cites W2159211108 @default.
- W2990456143 cites W2186740536 @default.
- W2990456143 cites W2326287562 @default.
- W2990456143 cites W2333233298 @default.
- W2990456143 cites W2467977699 @default.
- W2990456143 cites W2537122513 @default.
- W2990456143 cites W2589517828 @default.
- W2990456143 cites W2598304221 @default.
- W2990456143 cites W2712656447 @default.
- W2990456143 cites W2767814207 @default.
- W2990456143 cites W2791283433 @default.
- W2990456143 cites W2803823316 @default.
- W2990456143 cites W2883883478 @default.
- W2990456143 cites W4206503100 @default.
- W2990456143 cites W1555104854 @default.
- W2990456143 doi "https://doi.org/10.1155/2019/1695189" @default.
- W2990456143 hasPublicationYear "2019" @default.
- W2990456143 type Work @default.
- W2990456143 sameAs 2990456143 @default.
- W2990456143 citedByCount "16" @default.
- W2990456143 countsByYear W29904561432020 @default.
- W2990456143 countsByYear W29904561432021 @default.
- W2990456143 countsByYear W29904561432022 @default.
- W2990456143 countsByYear W29904561432023 @default.
- W2990456143 crossrefType "journal-article" @default.
- W2990456143 hasAuthorship W2990456143A5026947736 @default.
- W2990456143 hasAuthorship W2990456143A5028295433 @default.
- W2990456143 hasAuthorship W2990456143A5035347230 @default.
- W2990456143 hasAuthorship W2990456143A5047699193 @default.
- W2990456143 hasAuthorship W2990456143A5047737345 @default.
- W2990456143 hasAuthorship W2990456143A5055987122 @default.
- W2990456143 hasAuthorship W2990456143A5058806588 @default.
- W2990456143 hasAuthorship W2990456143A5060512022 @default.
- W2990456143 hasBestOaLocation W29904561431 @default.
- W2990456143 hasConcept C125287762 @default.
- W2990456143 hasConcept C13965031 @default.
- W2990456143 hasConcept C14631669 @default.
- W2990456143 hasConcept C155574463 @default.
- W2990456143 hasConcept C155672457 @default.
- W2990456143 hasConcept C159985019 @default.
- W2990456143 hasConcept C171250308 @default.