FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990475594> ?p ?o ?g. }

• W2990475594 endingPage "109" @default.
• W2990475594 startingPage "65" @default.
• W2990475594 abstract "Pattern recognition receptors (PRRs) are a key part of the innate immune system, the body's first line of defense against infection and tissue damage. This superfamily of receptors including Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin-like receptors (CLRs) and RIG-like receptors (RLRs) are responsible for initiation of the inflammatory response by their recognition of molecular patterns present in invading microorganisms (such as bacteria, viruses or fungi) during infection or in molecules released following tissue damage during acute or chronic disease states (such as sepsis or arthritis). These receptors are widely expressed and located on the cell surface, in intracellular compartments or in the cytoplasm can detect a single or subset of molecules including lipoproteins, carbohydrates or nucleic acids. In response, they initiate an intracellular signaling cascade that culminates in the synthesis and release of cytokines, chemokines and vasoactive molecules. These steps are necessary to maintain tissue homeostasis and remove potentially dangerous pathogens. However, during extreme or acute responses or during chronic disease, this can be damaging and even lead to death. Therefore, it is thought that targeting such receptors may offer a therapeutic approach in chronic inflammatory diseases or in cases of acute infection leading to sepsis. Herein, the current knowledge on the molecular biology of PRRs is reviewed along with their association with inflammatory and infectious diseases. Finally, the testing of therapeutic compounds and their future merit as targets is discussed." @default.
• W2990475594 created "2019-12-05" @default.
• W2990475594 creator A5079025508 @default.
• W2990475594 date "2020-01-01" @default.
• W2990475594 modified "2023-10-17" @default.
• W2990475594 title "Pattern recognition receptors as potential drug targets in inflammatory disorders" @default.
• W2990475594 cites W1176162522 @default.
• W2990475594 cites W1519633296 @default.
• W2990475594 cites W1519835538 @default.
• W2990475594 cites W1561041814 @default.
• W2990475594 cites W1632664444 @default.
• W2990475594 cites W1642457845 @default.
• W2990475594 cites W1690266880 @default.
• W2990475594 cites W1712659663 @default.
• W2990475594 cites W1778809153 @default.
• W2990475594 cites W1964354442 @default.
• W2990475594 cites W1971890346 @default.
• W2990475594 cites W1972724111 @default.
• W2990475594 cites W1972799331 @default.
• W2990475594 cites W1974070734 @default.
• W2990475594 cites W1974101555 @default.
• W2990475594 cites W1975026318 @default.
• W2990475594 cites W1981315004 @default.
• W2990475594 cites W1982027655 @default.
• W2990475594 cites W1982029015 @default.
• W2990475594 cites W1982637996 @default.
• W2990475594 cites W1990639420 @default.
• W2990475594 cites W1991083095 @default.
• W2990475594 cites W1995744610 @default.
• W2990475594 cites W1996671942 @default.
• W2990475594 cites W2003634035 @default.
• W2990475594 cites W2004465286 @default.
• W2990475594 cites W2007265326 @default.
• W2990475594 cites W2009420993 @default.
• W2990475594 cites W2012272570 @default.
• W2990475594 cites W2012569494 @default.
• W2990475594 cites W2017883909 @default.
• W2990475594 cites W2023718084 @default.
• W2990475594 cites W2024383625 @default.
• W2990475594 cites W2025065287 @default.
• W2990475594 cites W2025412364 @default.
• W2990475594 cites W2025859766 @default.
• W2990475594 cites W2026074634 @default.
• W2990475594 cites W2026500006 @default.
• W2990475594 cites W2028131879 @default.
• W2990475594 cites W2028171970 @default.
• W2990475594 cites W2028627944 @default.
• W2990475594 cites W2030611349 @default.
• W2990475594 cites W2031084334 @default.
• W2990475594 cites W2034708798 @default.
• W2990475594 cites W2034722126 @default.
• W2990475594 cites W2036606290 @default.
• W2990475594 cites W2037478127 @default.
• W2990475594 cites W2040101069 @default.
• W2990475594 cites W2043202073 @default.
• W2990475594 cites W2043697982 @default.
• W2990475594 cites W2047061140 @default.
• W2990475594 cites W2049261838 @default.
• W2990475594 cites W2052798287 @default.
• W2990475594 cites W2053189438 @default.
• W2990475594 cites W2053357534 @default.
• W2990475594 cites W2054186726 @default.
• W2990475594 cites W2057107002 @default.
• W2990475594 cites W2059654418 @default.
• W2990475594 cites W2060122053 @default.
• W2990475594 cites W2060351820 @default.
• W2990475594 cites W2065241877 @default.
• W2990475594 cites W2067877288 @default.
• W2990475594 cites W2069981713 @default.
• W2990475594 cites W2071670416 @default.
• W2990475594 cites W2071754972 @default.
• W2990475594 cites W2073382731 @default.
• W2990475594 cites W2076361525 @default.
• W2990475594 cites W2077486035 @default.
• W2990475594 cites W2077718534 @default.
• W2990475594 cites W2077871758 @default.
• W2990475594 cites W2078376325 @default.
• W2990475594 cites W2086607027 @default.
• W2990475594 cites W2088164523 @default.
• W2990475594 cites W2089428446 @default.
• W2990475594 cites W2089722005 @default.
• W2990475594 cites W2095833996 @default.
• W2990475594 cites W2097121808 @default.
• W2990475594 cites W2099873437 @default.
• W2990475594 cites W2100419933 @default.
• W2990475594 cites W2101006270 @default.
• W2990475594 cites W2101918575 @default.
• W2990475594 cites W2102764783 @default.
• W2990475594 cites W2102906662 @default.
• W2990475594 cites W2103851237 @default.
• W2990475594 cites W2104472257 @default.
• W2990475594 cites W2104722369 @default.
• W2990475594 cites W2105221079 @default.
• W2990475594 cites W2108375278 @default.
• W2990475594 cites W2109403608 @default.
• W2990475594 cites W2109491705 @default.
• W2990475594 cites W2110223162 @default.
• W2990475594 cites W2110372095 @default.

• next