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• W2990477127 abstract "Objective: To study the contribution of γδ T cells to the persistent HIV reservoir. Design: Fifteen HIV-seropositive individuals on suppressive ART were included. We performed parallel quantitative viral outgrowth assays (QVOA) of resting CD4 + T (rCD4) cells in the presence or absence of γδ T cells. Methods: Resting αβ+CD4 + T cells were magnetically isolated from PBMCs using two different custom cocktails, only one kit contained antibodies to deplete γδ T cells, resulting in two populations: rCD4 cells and rCD4 cells depleted of γδ cells. Frequency of infection was analyzed by QVOA and DNA measurements. Results: Recovery of replication-competent HIV from cultures of rCD4 cells was similar in 11 individuals despite the presence of γδ T cells. In four donors, HIV recovery was lower when γδ T cells were present. Expression of the cytotoxic marker CD16 + on Vδ2 cells was the only variable associated with the lower HIV recovery. Our results highlight the potency of those responses since a mean of 10 000 γδ T cells were present within 2.5 million rCD4 cells. However, despite the low frequency of γδ T cells, the presence of cytotoxic Vδ2 cells correlated with lower HIV recovery from cultures of rCD4 cells. Conclusion: Results of this study show that quantification of the contribution of γδ T cells to the reservoir is challenging because of their low numbers compared with conventional rCD4 cells and highlights the potent antiviral function of γδ T cells and the impact of their presence on the frequency of latent HIV infection." @default.
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• W2990477127 date "2020-03-01" @default.
• W2990477127 modified "2023-10-03" @default.
• W2990477127 title "Measuring the contribution of γδ T cells to the persistent HIV reservoir" @default.
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• W2990477127 doi "https://doi.org/10.1097/qad.0000000000002434" @default.
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