Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990479953> ?p ?o ?g. }
- W2990479953 endingPage "2047" @default.
- W2990479953 startingPage "2047" @default.
- W2990479953 abstract "In atherosclerosis, macrophages in the arterial wall ingest plasma lipoprotein-derived lipids and become lipid-filled foam cells with a limited lifespan. Thus, efficient removal of apoptotic foam cells by efferocytic macrophages is vital to preventing the dying foam cells from forming a large necrotic lipid core, which, otherwise, would render the atherosclerotic plaque vulnerable to rupture and would cause clinical complications. Ca2+ plays a role in macrophage migration, survival, and foam cell generation. Importantly, in efferocytic macrophages, Ca2+ induces actin polymerization, thereby promoting the formation of a phagocytic cup necessary for efferocytosis. Moreover, in the efferocytic macrophages, Ca2+ enhances the secretion of anti-inflammatory cytokines. Various Ca2+ antagonists have been seminal for the demonstration of the role of Ca2+ in the multiple steps of efferocytosis by macrophages. Moreover, in vitro and in vivo experiments and clinical investigations have revealed the capability of Ca2+ antagonists in attenuating the development of atherosclerotic plaques by interfering with the deposition of lipids in macrophages and by reducing plaque calcification. However, the regulation of cellular Ca2+ fluxes in the processes of efferocytic clearance of apoptotic foam cells and in the extracellular calcification in atherosclerosis remains unknown. Here, we attempted to unravel the molecular links between Ca2+ and efferocytosis in atherosclerosis and to evaluate cellular Ca2+ fluxes as potential treatment targets in atherosclerotic cardiovascular diseases." @default.
- W2990479953 created "2019-12-05" @default.
- W2990479953 creator A5031560022 @default.
- W2990479953 creator A5046431472 @default.
- W2990479953 creator A5053191492 @default.
- W2990479953 creator A5060135294 @default.
- W2990479953 creator A5085875890 @default.
- W2990479953 date "2019-11-21" @default.
- W2990479953 modified "2023-09-29" @default.
- W2990479953 title "Ca2+ Flux: Searching for a Role in Efferocytosis of Apoptotic Cells in Atherosclerosis" @default.
- W2990479953 cites W1485297825 @default.
- W2990479953 cites W1500581977 @default.
- W2990479953 cites W1546277730 @default.
- W2990479953 cites W1575682645 @default.
- W2990479953 cites W1580532947 @default.
- W2990479953 cites W1585052929 @default.
- W2990479953 cites W1591092186 @default.
- W2990479953 cites W1623540772 @default.
- W2990479953 cites W1626382598 @default.
- W2990479953 cites W1871204376 @default.
- W2990479953 cites W1928640509 @default.
- W2990479953 cites W1952064631 @default.
- W2990479953 cites W1964911306 @default.
- W2990479953 cites W1966936568 @default.
- W2990479953 cites W1967349402 @default.
- W2990479953 cites W1967369695 @default.
- W2990479953 cites W1969709153 @default.
- W2990479953 cites W1973457181 @default.
- W2990479953 cites W1974596072 @default.
- W2990479953 cites W1977056770 @default.
- W2990479953 cites W1977603207 @default.
- W2990479953 cites W1978442615 @default.
- W2990479953 cites W1979714374 @default.
- W2990479953 cites W1980484085 @default.
- W2990479953 cites W1995483143 @default.
- W2990479953 cites W1997557110 @default.
- W2990479953 cites W1998143581 @default.
- W2990479953 cites W1999227957 @default.
- W2990479953 cites W1999957358 @default.
- W2990479953 cites W2000313374 @default.
- W2990479953 cites W2001399725 @default.
- W2990479953 cites W2001644952 @default.
- W2990479953 cites W2001695277 @default.
- W2990479953 cites W2001917660 @default.
- W2990479953 cites W2002231317 @default.
- W2990479953 cites W2002487087 @default.
- W2990479953 cites W2002768720 @default.
- W2990479953 cites W2004410658 @default.
- W2990479953 cites W2007106585 @default.
- W2990479953 cites W2010572143 @default.
- W2990479953 cites W2011573742 @default.
- W2990479953 cites W2011906296 @default.
- W2990479953 cites W2013646121 @default.
- W2990479953 cites W2014100516 @default.
- W2990479953 cites W2016015763 @default.
- W2990479953 cites W2016291847 @default.
- W2990479953 cites W2017334048 @default.
- W2990479953 cites W2018800923 @default.
- W2990479953 cites W2022023024 @default.
- W2990479953 cites W2023441054 @default.
- W2990479953 cites W2023455126 @default.
- W2990479953 cites W2025466490 @default.
- W2990479953 cites W2027278652 @default.
- W2990479953 cites W2027356789 @default.
- W2990479953 cites W2027810531 @default.
- W2990479953 cites W2031239155 @default.
- W2990479953 cites W2031325281 @default.
- W2990479953 cites W2033796232 @default.
- W2990479953 cites W2034244149 @default.
- W2990479953 cites W2035601236 @default.
- W2990479953 cites W2036145275 @default.
- W2990479953 cites W2038048357 @default.
- W2990479953 cites W2051961989 @default.
- W2990479953 cites W2054555516 @default.
- W2990479953 cites W2054877904 @default.
- W2990479953 cites W2059930172 @default.
- W2990479953 cites W2063040523 @default.
- W2990479953 cites W2064521056 @default.
- W2990479953 cites W2065955320 @default.
- W2990479953 cites W2068822177 @default.
- W2990479953 cites W2070268146 @default.
- W2990479953 cites W2070461863 @default.
- W2990479953 cites W2071717526 @default.
- W2990479953 cites W2072680312 @default.
- W2990479953 cites W2073991959 @default.
- W2990479953 cites W2074102438 @default.
- W2990479953 cites W2074502503 @default.
- W2990479953 cites W2075318281 @default.
- W2990479953 cites W2077603983 @default.
- W2990479953 cites W2077726278 @default.
- W2990479953 cites W2081250995 @default.
- W2990479953 cites W2081562309 @default.
- W2990479953 cites W2081810806 @default.
- W2990479953 cites W2082191320 @default.
- W2990479953 cites W2083727066 @default.
- W2990479953 cites W2084088993 @default.
- W2990479953 cites W2084117223 @default.
- W2990479953 cites W2086918192 @default.