Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990510102> ?p ?o ?g. }
- W2990510102 endingPage "108" @default.
- W2990510102 startingPage "108" @default.
- W2990510102 abstract "In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), and TRPA (ankyrin), that are strictly connected with cancer cell proliferation, differentiation, cell death, angiogenesis, migration, and invasion. Changes in TRP channels’ expression and function have been found to regulate cell proliferation and resistance or sensitivity of cancer cells to apoptotic-induced cell death, resulting in cancer-promoting effects or resistance to chemotherapy treatments. This review summarizes the data reported so far on the effect of targeting TRP channels in different types of cancer by using multiple TRP-specific agonists, antagonists alone, or in combination with classic chemotherapeutic agents, microRNA specifically targeting the TRP channels, and so forth, and the in vitro and in vivo feasibility evaluated in experimental models and in cancer patients. Considerable efforts have been made to fight cancer cells, and therapies targeting TRP channels seem to be the most promising strategy. However, more in-depth investigations are required to completely understand the role of TRP channels in cancer in order to design new, more specific, and valuable pharmacological tools." @default.
- W2990510102 created "2019-12-05" @default.
- W2990510102 creator A5007630725 @default.
- W2990510102 creator A5021477463 @default.
- W2990510102 creator A5055462856 @default.
- W2990510102 creator A5079690240 @default.
- W2990510102 creator A5086612949 @default.
- W2990510102 date "2019-11-30" @default.
- W2990510102 modified "2023-10-01" @default.
- W2990510102 title "Transient Receptor Potential Cation Channels in Cancer Therapy" @default.
- W2990510102 cites W144423133 @default.
- W2990510102 cites W1489240885 @default.
- W2990510102 cites W1514075515 @default.
- W2990510102 cites W1565310864 @default.
- W2990510102 cites W1590223761 @default.
- W2990510102 cites W1598010884 @default.
- W2990510102 cites W1606213097 @default.
- W2990510102 cites W1606789163 @default.
- W2990510102 cites W1653897465 @default.
- W2990510102 cites W1895906477 @default.
- W2990510102 cites W1952500907 @default.
- W2990510102 cites W1970840710 @default.
- W2990510102 cites W1979707645 @default.
- W2990510102 cites W1982872797 @default.
- W2990510102 cites W1985346469 @default.
- W2990510102 cites W1985997104 @default.
- W2990510102 cites W1997735875 @default.
- W2990510102 cites W1999212252 @default.
- W2990510102 cites W1999407700 @default.
- W2990510102 cites W2006348947 @default.
- W2990510102 cites W2011107768 @default.
- W2990510102 cites W2011551149 @default.
- W2990510102 cites W2013800526 @default.
- W2990510102 cites W2019879792 @default.
- W2990510102 cites W2019915688 @default.
- W2990510102 cites W2021603715 @default.
- W2990510102 cites W2026170663 @default.
- W2990510102 cites W2027752491 @default.
- W2990510102 cites W2036921031 @default.
- W2990510102 cites W2040154301 @default.
- W2990510102 cites W2040393174 @default.
- W2990510102 cites W2040563649 @default.
- W2990510102 cites W2045748219 @default.
- W2990510102 cites W2050869737 @default.
- W2990510102 cites W2053680377 @default.
- W2990510102 cites W2062897287 @default.
- W2990510102 cites W2063085360 @default.
- W2990510102 cites W2066346206 @default.
- W2990510102 cites W2067170675 @default.
- W2990510102 cites W2071145060 @default.
- W2990510102 cites W2075802597 @default.
- W2990510102 cites W2076806011 @default.
- W2990510102 cites W2076992552 @default.
- W2990510102 cites W2084534079 @default.
- W2990510102 cites W2086190614 @default.
- W2990510102 cites W2090124972 @default.
- W2990510102 cites W2090164016 @default.
- W2990510102 cites W2092893542 @default.
- W2990510102 cites W2093258669 @default.
- W2990510102 cites W2099586601 @default.
- W2990510102 cites W2100829842 @default.
- W2990510102 cites W2101696060 @default.
- W2990510102 cites W2106916570 @default.
- W2990510102 cites W2107057422 @default.
- W2990510102 cites W2113696322 @default.
- W2990510102 cites W2127420494 @default.
- W2990510102 cites W2128328621 @default.
- W2990510102 cites W2129155568 @default.
- W2990510102 cites W2129809987 @default.
- W2990510102 cites W2130420429 @default.
- W2990510102 cites W2130979840 @default.
- W2990510102 cites W2132988229 @default.
- W2990510102 cites W2133448591 @default.
- W2990510102 cites W2133535821 @default.
- W2990510102 cites W2139149736 @default.
- W2990510102 cites W2141169703 @default.
- W2990510102 cites W2149348468 @default.
- W2990510102 cites W2156065100 @default.
- W2990510102 cites W2164157263 @default.
- W2990510102 cites W2165491366 @default.
- W2990510102 cites W2169774852 @default.
- W2990510102 cites W2270658981 @default.
- W2990510102 cites W2280796933 @default.
- W2990510102 cites W2312180837 @default.
- W2990510102 cites W2320219233 @default.
- W2990510102 cites W2331071731 @default.
- W2990510102 cites W2338328436 @default.
- W2990510102 cites W2398176300 @default.
- W2990510102 cites W2509573027 @default.
- W2990510102 cites W2555600425 @default.
- W2990510102 cites W2564563599 @default.
- W2990510102 cites W2584060755 @default.
- W2990510102 cites W2585936581 @default.
- W2990510102 cites W2591538880 @default.
- W2990510102 cites W2593410720 @default.
- W2990510102 cites W2593816799 @default.
- W2990510102 cites W2600059812 @default.
- W2990510102 cites W2602492249 @default.