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• W2990527439 abstract "MicroRNAs (miRNAs) have been reported to be involved in tumor metastasis. In this study, we investigated the function of miR-506 in the metastasis of human hepatocellular carcinoma (HCC). We found that miR-506 is significantly downregulated in the primary tissue of metastatic HCC and in highly metastatic HCC cell lines. Overexpression of miR-506 suppressed HCC cell migration, invasion, and metastasis both in vitro and in vivo. Furthermore, miR-506 was found to specifically target the 3' untranslated region (3'-UTR) of interleukin 8 (IL8) mRNA. Spearman's correlation analysis revealed that miR-506 expression inversely correlated with IL8 mRNA and protein expression in HCC tissue samples. IL8 treatment reversed miR-506-induced suppression of HCC cell migration and invasiveness. Thus, miR-506 acts as a tumor suppressor that may inhibit the migration, invasiveness, and metastasis of HCC cells by targeting IL8." @default.
• W2990527439 created "2019-12-05" @default.
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• W2990527439 date "2018-01-01" @default.
• W2990527439 modified "2023-10-16" @default.
• W2990527439 title "MicroRNA-506 suppresses invasiveness and metastasis of human hepatocellular carcinoma cells by targeting IL8." @default.
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• W2990527439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129486" @default.
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