FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990537701> ?p ?o ?g. }

• W2990537701 endingPage "1423" @default.
• W2990537701 startingPage "1413" @default.
• W2990537701 abstract "Development of cancer vaccines targeting tumor self-antigens is complex and challenging due to the difficulty of overcoming immune tolerance to self-proteins. Vaccination against tumor self-protein D52 (D52) has been successful, although complete protection appears impaired by immune regulation. Our previous studies suggest that vaccine elicited CD8 + T cells producing interleukin 10 (IL-10) may have a negative impact on tumor protection. Understanding the role CD8+ IL-10 + T cells play in the immune response following vaccination with D52 could result in a more potent vaccine. To address this, we vaccinated IL-10 deficient mice with the murine orthologue of D52; vaccination of wild type (wt) C57BL/6J served as a control for comparison. In separate experiments, D52 vaccinated wt mice were administered IL-10R-specific mAb to neutralize IL-10 function. Interestingly, we observed similar protection against primary tumor challenge in the experimental groups compared to the controls. However, individual IL-10 deficient mice that rejected the primary tumor challenge were re-challenged 140 days post-primary challenge to access vaccine durability and immunologic memory against tumor recurrence. Mice deficient in IL-10 demonstrated a memory response in which 100% of the mice were protected from secondary tumor challenge, while wt mice had diminished recall response (25%) against tumor recurrence. These results with analysis of vaccine-elicited CD8 + T cells for tumor-specific killing and regulatory cell marker expression, add further support to our premise that CD8+ IL-10 + T cells elicited by D52 tumor-self protein vaccine contribute to the suppression of a memory CTL responses and durable tumor immunity." @default.
• W2990537701 created "2019-12-05" @default.
• W2990537701 creator A5047301970 @default.
• W2990537701 creator A5070238702 @default.
• W2990537701 creator A5078893893 @default.
• W2990537701 creator A5084971557 @default.
• W2990537701 date "2019-11-26" @default.
• W2990537701 modified "2023-09-26" @default.
• W2990537701 title "Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52" @default.
• W2990537701 cites W1575489109 @default.
• W2990537701 cites W1602627378 @default.
• W2990537701 cites W1965807814 @default.
• W2990537701 cites W1968064568 @default.
• W2990537701 cites W1975869295 @default.
• W2990537701 cites W1976933312 @default.
• W2990537701 cites W2002100910 @default.
• W2990537701 cites W2004951070 @default.
• W2990537701 cites W2009029469 @default.
• W2990537701 cites W2010638587 @default.
• W2990537701 cites W2011319298 @default.
• W2990537701 cites W2018519520 @default.
• W2990537701 cites W2036021688 @default.
• W2990537701 cites W2037337113 @default.
• W2990537701 cites W2043476265 @default.
• W2990537701 cites W2048758805 @default.
• W2990537701 cites W2049946738 @default.
• W2990537701 cites W2067939508 @default.
• W2990537701 cites W2099433891 @default.
• W2990537701 cites W2104501624 @default.
• W2990537701 cites W2106843579 @default.
• W2990537701 cites W2122046935 @default.
• W2990537701 cites W2125200489 @default.
• W2990537701 cites W2127077454 @default.
• W2990537701 cites W2133123802 @default.
• W2990537701 cites W2133131759 @default.
• W2990537701 cites W2133301992 @default.
• W2990537701 cites W2134868528 @default.
• W2990537701 cites W2136180772 @default.
• W2990537701 cites W2146226600 @default.
• W2990537701 cites W2149227522 @default.
• W2990537701 cites W2155139751 @default.
• W2990537701 cites W2156100443 @default.
• W2990537701 cites W2156592930 @default.
• W2990537701 cites W2157995908 @default.
• W2990537701 cites W2160908140 @default.
• W2990537701 cites W2161074777 @default.
• W2990537701 cites W2169394657 @default.
• W2990537701 cites W2169770330 @default.
• W2990537701 cites W2170001969 @default.
• W2990537701 cites W2183804143 @default.
• W2990537701 cites W2922723823 @default.
• W2990537701 doi "https://doi.org/10.1080/21645515.2019.1689746" @default.
• W2990537701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7482783" @default.
• W2990537701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31769704" @default.
• W2990537701 hasPublicationYear "2019" @default.
• W2990537701 type Work @default.
• W2990537701 sameAs 2990537701 @default.
• W2990537701 citedByCount "1" @default.
• W2990537701 countsByYear W29905377012022 @default.
• W2990537701 crossrefType "journal-article" @default.
• W2990537701 hasAuthorship W2990537701A5047301970 @default.
• W2990537701 hasAuthorship W2990537701A5070238702 @default.
• W2990537701 hasAuthorship W2990537701A5078893893 @default.
• W2990537701 hasAuthorship W2990537701A5084971557 @default.
• W2990537701 hasBestOaLocation W29905377011 @default.
• W2990537701 hasConcept C147483822 @default.
• W2990537701 hasConcept C154317977 @default.
• W2990537701 hasConcept C167672396 @default.
• W2990537701 hasConcept C202751555 @default.
• W2990537701 hasConcept C203014093 @default.
• W2990537701 hasConcept C22070199 @default.
• W2990537701 hasConcept C54355233 @default.
• W2990537701 hasConcept C86803240 @default.
• W2990537701 hasConcept C8891405 @default.
• W2990537701 hasConceptScore W2990537701C147483822 @default.
• W2990537701 hasConceptScore W2990537701C154317977 @default.
• W2990537701 hasConceptScore W2990537701C167672396 @default.
• W2990537701 hasConceptScore W2990537701C202751555 @default.
• W2990537701 hasConceptScore W2990537701C203014093 @default.
• W2990537701 hasConceptScore W2990537701C22070199 @default.
• W2990537701 hasConceptScore W2990537701C54355233 @default.
• W2990537701 hasConceptScore W2990537701C86803240 @default.
• W2990537701 hasConceptScore W2990537701C8891405 @default.
• W2990537701 hasFunder F4320337351 @default.
• W2990537701 hasIssue "6" @default.
• W2990537701 hasLocation W29905377011 @default.
• W2990537701 hasLocation W29905377012 @default.
• W2990537701 hasLocation W29905377013 @default.
• W2990537701 hasOpenAccess W2990537701 @default.
• W2990537701 hasPrimaryLocation W29905377011 @default.
• W2990537701 hasRelatedWork W155301942 @default.
• W2990537701 hasRelatedWork W2001055320 @default.
• W2990537701 hasRelatedWork W2008949385 @default.
• W2990537701 hasRelatedWork W2019574320 @default.
• W2990537701 hasRelatedWork W2031356189 @default.
• W2990537701 hasRelatedWork W2149871822 @default.
• W2990537701 hasRelatedWork W2220102944 @default.
• W2990537701 hasRelatedWork W2409441623 @default.

• next