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- W2990546013 abstract "Abstract Objective An early reduction of adult invasive pneumococcal disease (IPD) was observed after the 13-valent pneumococcal conjugate vaccine (PCV13) introduction for children in Spain. We analysed the epidemiology of adult IPD in the late-PCV13 period. Methods This was a prospective multicentre study of adult IPD involving six hospitals. Strains were serotyped, genotyped and studied for antimicrobial susceptibility. The late-PCV13 period was compared with the pre- and early-PCV13 periods. Results A total of 2197 episodes were collected—949 in 2008–2009, 609 in 2012–2013 and 639 in 2015–2016. The initial decrease of IPD observed (from 12.3/100 000 to 8.1/100 000; 2008–2009 versus 2012–2013) plateaued in 2015–2016 (8.3/100 000). IPD due to PCV13 serotypes decreased (from 7.7 to 3.5 to 2.3/100 000; p Conclusions The initial decrease of adult IPD observed after PCV13 introduction for children has been balanced by the rise of non-PCV13 serotypes. The spread of antibiotic-resistant lineages related to non-PCV13 serotypes (11A and 24F) could be a threat for the treatment of serious pneumococcal diseases." @default.
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- W2990546013 date "2020-06-01" @default.
- W2990546013 modified "2023-10-15" @default.
- W2990546013 title "Emerging non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes causing adult invasive pneumococcal disease in the late-PCV13 period in Spain" @default.
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- W2990546013 doi "https://doi.org/10.1016/j.cmi.2019.10.034" @default.
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