FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990564597> ?p ?o ?g. }

• W2990564597 endingPage "9999" @default.
• W2990564597 startingPage "9982" @default.
• W2990564597 abstract "This study investigates the role of circular RNA (circRNA) hsa_circ_0000515 in cervical cancer and the underlying mechanism associated with microRNA-326 (miR-326). hsa_circ_0000515 and ETS transcription factor ELK1 (ELK1) were initially over-expressed and miR-326 was down-regulated in cervical cancer tissues and cells. Low hsa_circ_0000515 expression was found to be associated with favorable prognosis of patients with cervical cancer. A series of mimics, inhibitors, over-expression plasmids or siRNAs were introduced into cervical cancer cells to alter the expression of hsa_circ_0000515, miR-326 and ELK1. In vitro experiments exhibited that silencing of hsa_circ_0000515 or upregulation of miR-326 resulted in suppressed proliferation and invasion, along with induced apoptosis and autophagy of cervical cancer cells. Dual-luciferase reporter assay, RNA pull-down and RIP assays highlighted that hsa_circ_0000515 was able to act as a ceRNA of miR-326 to increase ELK1. Furthermore, enhancement of ELK1 expression resulted in enhanced proliferation and invasion but repressed apoptosis and autophagy of cervical cancer cells. In vivo experiments further confirmed the suppressed tumor growth by hsa_circ_0000515 silencing. Our findings demonstrated that hsa_circ_0000515 acts as a tumor promoter in cervical cancer. The study provides evidence for targeting hsa_circ_0000515 for therapeutic purposes in treating cervical cancer." @default.
• W2990564597 created "2019-12-05" @default.
• W2990564597 creator A5010241534 @default.
• W2990564597 creator A5035904324 @default.
• W2990564597 creator A5037354764 @default.
• W2990564597 creator A5085671322 @default.
• W2990564597 date "2019-11-26" @default.
• W2990564597 modified "2023-10-17" @default.
• W2990564597 title "Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1" @default.
• W2990564597 cites W2009320874 @default.
• W2990564597 cites W2017919052 @default.
• W2990564597 cites W2052591083 @default.
• W2990564597 cites W2054998944 @default.
• W2990564597 cites W2071593083 @default.
• W2990564597 cites W2081098333 @default.
• W2990564597 cites W2130687298 @default.
• W2990564597 cites W2156667412 @default.
• W2990564597 cites W2284415752 @default.
• W2990564597 cites W2406517728 @default.
• W2990564597 cites W2416149666 @default.
• W2990564597 cites W2515912686 @default.
• W2990564597 cites W2575837388 @default.
• W2990564597 cites W2595699959 @default.
• W2990564597 cites W2603969536 @default.
• W2990564597 cites W2617246751 @default.
• W2990564597 cites W2741267269 @default.
• W2990564597 cites W2741541139 @default.
• W2990564597 cites W2754545492 @default.
• W2990564597 cites W2766520601 @default.
• W2990564597 cites W2775040869 @default.
• W2990564597 cites W2783169572 @default.
• W2990564597 cites W2791173369 @default.
• W2990564597 cites W2791808804 @default.
• W2990564597 cites W2801173103 @default.
• W2990564597 cites W2802275807 @default.
• W2990564597 cites W2862248209 @default.
• W2990564597 cites W2884692871 @default.
• W2990564597 cites W2889679530 @default.
• W2990564597 cites W2891194910 @default.
• W2990564597 cites W2897729287 @default.
• W2990564597 cites W2898216546 @default.
• W2990564597 cites W2899095398 @default.
• W2990564597 cites W2901172901 @default.
• W2990564597 cites W2903491648 @default.
• W2990564597 cites W2904602238 @default.
• W2990564597 cites W2905050494 @default.
• W2990564597 cites W2906131344 @default.
• W2990564597 cites W2906897143 @default.
• W2990564597 cites W2910599425 @default.
• W2990564597 cites W2911188335 @default.
• W2990564597 cites W2915506721 @default.
• W2990564597 cites W2964277580 @default.
• W2990564597 cites W2989667815 @default.
• W2990564597 cites W4211097225 @default.
• W2990564597 doi "https://doi.org/10.18632/aging.102356" @default.
• W2990564597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6914414" @default.
• W2990564597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31772143" @default.
• W2990564597 hasPublicationYear "2019" @default.
• W2990564597 type Work @default.
• W2990564597 sameAs 2990564597 @default.
• W2990564597 citedByCount "106" @default.
• W2990564597 countsByYear W29905645972019 @default.
• W2990564597 countsByYear W29905645972020 @default.
• W2990564597 countsByYear W29905645972021 @default.
• W2990564597 countsByYear W29905645972022 @default.
• W2990564597 countsByYear W29905645972023 @default.
• W2990564597 crossrefType "journal-article" @default.
• W2990564597 hasAuthorship W2990564597A5010241534 @default.
• W2990564597 hasAuthorship W2990564597A5035904324 @default.
• W2990564597 hasAuthorship W2990564597A5037354764 @default.
• W2990564597 hasAuthorship W2990564597A5085671322 @default.
• W2990564597 hasBestOaLocation W29905645971 @default.
• W2990564597 hasConcept C104317684 @default.
• W2990564597 hasConcept C119056186 @default.
• W2990564597 hasConcept C121608353 @default.
• W2990564597 hasConcept C126322002 @default.
• W2990564597 hasConcept C127561419 @default.
• W2990564597 hasConcept C145059251 @default.
• W2990564597 hasConcept C153911025 @default.
• W2990564597 hasConcept C166703698 @default.
• W2990564597 hasConcept C185592680 @default.
• W2990564597 hasConcept C190283241 @default.
• W2990564597 hasConcept C22615655 @default.
• W2990564597 hasConcept C2778220009 @default.
• W2990564597 hasConcept C502942594 @default.
• W2990564597 hasConcept C54009773 @default.
• W2990564597 hasConcept C55493867 @default.
• W2990564597 hasConcept C60365752 @default.
• W2990564597 hasConcept C62203573 @default.
• W2990564597 hasConcept C67705224 @default.
• W2990564597 hasConcept C71924100 @default.
• W2990564597 hasConcept C86803240 @default.
• W2990564597 hasConceptScore W2990564597C104317684 @default.
• W2990564597 hasConceptScore W2990564597C119056186 @default.
• W2990564597 hasConceptScore W2990564597C121608353 @default.
• W2990564597 hasConceptScore W2990564597C126322002 @default.
• W2990564597 hasConceptScore W2990564597C127561419 @default.
• W2990564597 hasConceptScore W2990564597C145059251 @default.

• next