FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990588252> ?p ?o ?g. }

• W2990588252 endingPage "364" @default.
• W2990588252 startingPage "358" @default.
• W2990588252 abstract "Abstract Photodynamic therapy (PDT) with photosensitizer verteporfin is a clinically approved vascular disrupting modality that is currently in clinical trial for cancer treatment. In this study, we evaluated PDT in combination with either mTORC1 inhibitor rapamycin or mTORC1/C2 dual inhibitor AZD2014 for therapeutic enhancement in SVEC endothelial cells. Verteporfin‐PDT alone induced cell apoptosis by activating the intrinsic apoptotic pathway. However, it increased the expression of anti‐apoptotic protein MCL‐1 and the phosphorylation of S6, a downstream molecule of mTOR signaling. In contrast, mTOR inhibitors rapamycin and AZD2014 did not induce apoptosis in SVEC cells. They suppressed MCL‐1 expression and S6 phosphorylation and imposed a potent inhibition on cell proliferation. PDT in combination with mTOR inhibitors activated the intrinsic apoptotic pathway and resulted in increased apoptosis. Combination treatments also led to sustained inhibition of cell proliferation. Although AZD2014 was more effective for cell growth inhibition and PDT enhancement than rapamycin at the higher concentrations examined in the study, both inhibitors effectively enhanced PDT response, suggesting that inhibition of mTORC1 is crucial for PDT enhancement. Our results indicate that mTOR inhibitors mechanistically cooperate with PDT for enhanced cell death and sustained growth inhibition, supporting a combination approach for therapeutic enhancement." @default.
• W2990588252 created "2019-12-05" @default.
• W2990588252 creator A5047107337 @default.
• W2990588252 creator A5064069998 @default.
• W2990588252 creator A5077558284 @default.
• W2990588252 date "2019-12-17" @default.
• W2990588252 modified "2023-09-27" @default.
• W2990588252 title "Therapeutic Enhancement of Verteporfin‐mediated Photodynamic Therapy by mTOR Inhibitors" @default.
• W2990588252 cites W125312278 @default.
• W2990588252 cites W1873528488 @default.
• W2990588252 cites W1980402007 @default.
• W2990588252 cites W1987334812 @default.
• W2990588252 cites W2011528765 @default.
• W2990588252 cites W2013316743 @default.
• W2990588252 cites W2034008755 @default.
• W2990588252 cites W2037000177 @default.
• W2990588252 cites W2038497586 @default.
• W2990588252 cites W2039169563 @default.
• W2990588252 cites W2043272521 @default.
• W2990588252 cites W2046275434 @default.
• W2990588252 cites W2084393946 @default.
• W2990588252 cites W2085742024 @default.
• W2990588252 cites W2100968946 @default.
• W2990588252 cites W2101634100 @default.
• W2990588252 cites W2115010775 @default.
• W2990588252 cites W2118908749 @default.
• W2990588252 cites W2129227644 @default.
• W2990588252 cites W2137533452 @default.
• W2990588252 cites W2148309788 @default.
• W2990588252 cites W2148935327 @default.
• W2990588252 cites W2151734986 @default.
• W2990588252 cites W2163767410 @default.
• W2990588252 cites W2165094789 @default.
• W2990588252 cites W2563571637 @default.
• W2990588252 cites W2747765631 @default.
• W2990588252 cites W2896869836 @default.
• W2990588252 cites W2914538391 @default.
• W2990588252 cites W2948039455 @default.
• W2990588252 doi "https://doi.org/10.1111/php.13187" @default.
• W2990588252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7138740" @default.
• W2990588252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31769520" @default.
• W2990588252 hasPublicationYear "2019" @default.
• W2990588252 type Work @default.
• W2990588252 sameAs 2990588252 @default.
• W2990588252 citedByCount "6" @default.
• W2990588252 countsByYear W29905882522020 @default.
• W2990588252 countsByYear W29905882522022 @default.
• W2990588252 countsByYear W29905882522023 @default.
• W2990588252 crossrefType "journal-article" @default.
• W2990588252 hasAuthorship W2990588252A5047107337 @default.
• W2990588252 hasAuthorship W2990588252A5064069998 @default.
• W2990588252 hasAuthorship W2990588252A5077558284 @default.
• W2990588252 hasBestOaLocation W29905882522 @default.
• W2990588252 hasConcept C11960822 @default.
• W2990588252 hasConcept C178790620 @default.
• W2990588252 hasConcept C185592680 @default.
• W2990588252 hasConcept C190283241 @default.
• W2990588252 hasConcept C2780827179 @default.
• W2990588252 hasConcept C2781148688 @default.
• W2990588252 hasConcept C2781323092 @default.
• W2990588252 hasConcept C2781359195 @default.
• W2990588252 hasConcept C502942594 @default.
• W2990588252 hasConcept C55493867 @default.
• W2990588252 hasConcept C62112901 @default.
• W2990588252 hasConcept C86554907 @default.
• W2990588252 hasConcept C86803240 @default.
• W2990588252 hasConcept C95444343 @default.
• W2990588252 hasConcept C98490376 @default.
• W2990588252 hasConceptScore W2990588252C11960822 @default.
• W2990588252 hasConceptScore W2990588252C178790620 @default.
• W2990588252 hasConceptScore W2990588252C185592680 @default.
• W2990588252 hasConceptScore W2990588252C190283241 @default.
• W2990588252 hasConceptScore W2990588252C2780827179 @default.
• W2990588252 hasConceptScore W2990588252C2781148688 @default.
• W2990588252 hasConceptScore W2990588252C2781323092 @default.
• W2990588252 hasConceptScore W2990588252C2781359195 @default.
• W2990588252 hasConceptScore W2990588252C502942594 @default.
• W2990588252 hasConceptScore W2990588252C55493867 @default.
• W2990588252 hasConceptScore W2990588252C62112901 @default.
• W2990588252 hasConceptScore W2990588252C86554907 @default.
• W2990588252 hasConceptScore W2990588252C86803240 @default.
• W2990588252 hasConceptScore W2990588252C95444343 @default.
• W2990588252 hasConceptScore W2990588252C98490376 @default.
• W2990588252 hasFunder F4320332161 @default.
• W2990588252 hasIssue "2" @default.
• W2990588252 hasLocation W29905882521 @default.
• W2990588252 hasLocation W29905882522 @default.
• W2990588252 hasOpenAccess W2990588252 @default.
• W2990588252 hasPrimaryLocation W29905882521 @default.
• W2990588252 hasRelatedWork W1999741914 @default.
• W2990588252 hasRelatedWork W2016514257 @default.
• W2990588252 hasRelatedWork W2101083009 @default.
• W2990588252 hasRelatedWork W2118908749 @default.
• W2990588252 hasRelatedWork W2292304181 @default.
• W2990588252 hasRelatedWork W2499779639 @default.
• W2990588252 hasRelatedWork W2744183625 @default.
• W2990588252 hasRelatedWork W2990588252 @default.
• W2990588252 hasRelatedWork W3093469178 @default.

• next