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• W2990589822 endingPage "115643" @default.
• W2990589822 startingPage "115643" @default.
• W2990589822 abstract "Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, inflammation, immune response, tumor metastasis and in viral/bacterial/parasitic infections. However, it is difficult to obtain these naturally occurring glycoconjugates as they are often heterogeneous compositions, which causes batch-to-batch variability of structure and activity often leading an incomplete understanding of their mechanism of action. Thus, the efficient preparation of synthetic glycoconjugates, possessing well-defined compositions and reproducible biological properties is highly desirable. In the present review, we summarize the advances in site-selective approaches for glycoconjugate synthesis and, in particular, the preparation of polysaccharide vaccines." @default.
• W2990589822 created "2019-12-05" @default.
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• W2990589822 date "2020-02-01" @default.
• W2990589822 modified "2023-10-14" @default.
• W2990589822 title "Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development" @default.
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• W2990589822 doi "https://doi.org/10.1016/j.carbpol.2019.115643" @default.
• W2990589822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31887910" @default.
• W2990589822 hasPublicationYear "2020" @default.
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