Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990596543> ?p ?o ?g. }
- W2990596543 endingPage "1961" @default.
- W2990596543 startingPage "1961" @default.
- W2990596543 abstract "<ns4:p>Mastocytosis is a rare disease due to the abnormal accumulation of mast cells in various tissues. Its clinical presentation is heterogeneous depending on mast cell infiltration and mediators release. In some cases, it is associated with hematological malignancies. Prognosis varies from very good with a life expectancy similar to the general population in indolent forms of the disease to a survival time of just a few months in mast cell leukemia. Although in most cases a somatic <ns4:italic>KIT </ns4:italic>D816V mutation is found in tumor mast cells, the physiopathology of the disease is not yet fully understood. Additional germline and somatic mutations may explain this heterogeneity. Treatments aim at blocking effect of mast cell mediators, reducing mast cell activation and tumor burden. New drugs mainly directed against the tyrosine kinase activity of KIT have dramatically changed the quality of life and prognosis of mast cell diseases. Present and future therapeutic strategies are discussed in this review.</ns4:p>" @default.
- W2990596543 created "2019-12-05" @default.
- W2990596543 creator A5007732660 @default.
- W2990596543 creator A5027616397 @default.
- W2990596543 creator A5030593310 @default.
- W2990596543 creator A5056713429 @default.
- W2990596543 creator A5088509972 @default.
- W2990596543 creator A5091463936 @default.
- W2990596543 date "2019-11-22" @default.
- W2990596543 modified "2023-10-18" @default.
- W2990596543 title "Recent advances in the understanding and therapeutic management of mastocytosis" @default.
- W2990596543 cites W1494664247 @default.
- W2990596543 cites W1803135625 @default.
- W2990596543 cites W1953082779 @default.
- W2990596543 cites W1974100080 @default.
- W2990596543 cites W1975240950 @default.
- W2990596543 cites W1985989614 @default.
- W2990596543 cites W1987628847 @default.
- W2990596543 cites W1987946408 @default.
- W2990596543 cites W1993878351 @default.
- W2990596543 cites W1997177551 @default.
- W2990596543 cites W1998340990 @default.
- W2990596543 cites W2006786878 @default.
- W2990596543 cites W2012245921 @default.
- W2990596543 cites W2022452901 @default.
- W2990596543 cites W2032682785 @default.
- W2990596543 cites W2033518553 @default.
- W2990596543 cites W2042177066 @default.
- W2990596543 cites W2076177141 @default.
- W2990596543 cites W2089939456 @default.
- W2990596543 cites W2098253079 @default.
- W2990596543 cites W2103322585 @default.
- W2990596543 cites W2107590922 @default.
- W2990596543 cites W2109655246 @default.
- W2990596543 cites W2111935453 @default.
- W2990596543 cites W2113692004 @default.
- W2990596543 cites W2115823813 @default.
- W2990596543 cites W2121216306 @default.
- W2990596543 cites W2125328554 @default.
- W2990596543 cites W2126677578 @default.
- W2990596543 cites W2139464974 @default.
- W2990596543 cites W2142804979 @default.
- W2990596543 cites W2146597025 @default.
- W2990596543 cites W2156160133 @default.
- W2990596543 cites W2160198600 @default.
- W2990596543 cites W2161282346 @default.
- W2990596543 cites W2179483502 @default.
- W2990596543 cites W2279450383 @default.
- W2990596543 cites W2472403803 @default.
- W2990596543 cites W2535682874 @default.
- W2990596543 cites W2565342730 @default.
- W2990596543 cites W2568737301 @default.
- W2990596543 cites W2625389217 @default.
- W2990596543 cites W2726559579 @default.
- W2990596543 cites W2737266865 @default.
- W2990596543 cites W2741019664 @default.
- W2990596543 cites W2766898995 @default.
- W2990596543 cites W2787130891 @default.
- W2990596543 cites W2794139981 @default.
- W2990596543 cites W2794764165 @default.
- W2990596543 cites W2807207064 @default.
- W2990596543 cites W2876204665 @default.
- W2990596543 cites W2914596877 @default.
- W2990596543 cites W2927283647 @default.
- W2990596543 cites W841996061 @default.
- W2990596543 doi "https://doi.org/10.12688/f1000research.19463.1" @default.
- W2990596543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6880274" @default.
- W2990596543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31824655" @default.
- W2990596543 hasPublicationYear "2019" @default.
- W2990596543 type Work @default.
- W2990596543 sameAs 2990596543 @default.
- W2990596543 citedByCount "12" @default.
- W2990596543 countsByYear W29905965432020 @default.
- W2990596543 countsByYear W29905965432021 @default.
- W2990596543 countsByYear W29905965432022 @default.
- W2990596543 countsByYear W29905965432023 @default.
- W2990596543 crossrefType "journal-article" @default.
- W2990596543 hasAuthorship W2990596543A5007732660 @default.
- W2990596543 hasAuthorship W2990596543A5027616397 @default.
- W2990596543 hasAuthorship W2990596543A5030593310 @default.
- W2990596543 hasAuthorship W2990596543A5056713429 @default.
- W2990596543 hasAuthorship W2990596543A5088509972 @default.
- W2990596543 hasAuthorship W2990596543A5091463936 @default.
- W2990596543 hasBestOaLocation W29905965431 @default.
- W2990596543 hasConcept C104317684 @default.
- W2990596543 hasConcept C134305767 @default.
- W2990596543 hasConcept C142724271 @default.
- W2990596543 hasConcept C203014093 @default.
- W2990596543 hasConcept C2779134260 @default.
- W2990596543 hasConcept C2779726688 @default.
- W2990596543 hasConcept C2780581156 @default.
- W2990596543 hasConcept C2908647359 @default.
- W2990596543 hasConcept C502942594 @default.
- W2990596543 hasConcept C54355233 @default.
- W2990596543 hasConcept C71924100 @default.
- W2990596543 hasConcept C86803240 @default.
- W2990596543 hasConcept C99454951 @default.
- W2990596543 hasConceptScore W2990596543C104317684 @default.