FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990599467> ?p ?o ?g. }

• W2990599467 endingPage "9041" @default.
• W2990599467 startingPage "9028" @default.
• W2990599467 abstract "BACKGROUND:This study identified microRNAs (miRNAs) and mRNAs associated with Compound Longmaining (CLMN) treatment of acute myocardial infarction (AMI). Our results provide a theoretical framework to guide AMI treatment and improve myocardial injury. MATERIAL AND METHODS:The myocardial tissues of the sham operation group (S), the model group (M), and the CLMN treatment group (T) were obtained. The mRNA and miRNA expression profiles were identified using RNA-sequencing analysis. The sequencing results were verified by quantitative real-time PCR (qRT-PCR). Bioinformatics was used to predict the function of differentially expressed genes (DEGs) and related signal transduction pathways. The target genes of miRNAs were predicted by software analysis, and the relationship between miRNA and mRNA was studied by network analysis. RESULTS:RNA-sequencing revealed 22 differentially expressed miRNAs (DEMs) and 76 DEGs in myocardial tissue. Six DEMs and 9 DEGs were randomly selected for qRT-PCR validation, and corroborating results were obtained. The results of Gene ontology (GO) showed that DEGs participated in different biological processes. Through the combined analysis of miRNAs and mRNAs expression, it was confirmed that a single miRNA is involved in the regulation of multiple genes, and also multiple miRNAs can target one gene. CONCLUSIONS:The analysis based on the miRNA-mRNA network can not only help to elucidate the potential molecular mechanism of CLMN treatment of AMI, but can also help in identifying novel therapeutic targets." @default.
• W2990599467 created "2019-12-05" @default.
• W2990599467 creator A5017269103 @default.
• W2990599467 creator A5029984685 @default.
• W2990599467 creator A5032529955 @default.
• W2990599467 creator A5073036869 @default.
• W2990599467 date "2019-11-28" @default.
• W2990599467 modified "2023-10-17" @default.
• W2990599467 title "Integrative Analysis of Expression Profiles of MicroRNAs and mRNAs in Treatment of Acute Myocardial Infarction with Compound Longmaining Decoction" @default.
• W2990599467 cites W1967255096 @default.
• W2990599467 cites W2000051229 @default.
• W2990599467 cites W2008524866 @default.
• W2990599467 cites W2014946489 @default.
• W2990599467 cites W2029305763 @default.
• W2990599467 cites W2041318682 @default.
• W2990599467 cites W2041584470 @default.
• W2990599467 cites W2044221698 @default.
• W2990599467 cites W2049455628 @default.
• W2990599467 cites W2078348074 @default.
• W2990599467 cites W2088797440 @default.
• W2990599467 cites W2088926815 @default.
• W2990599467 cites W2094114187 @default.
• W2990599467 cites W2103239857 @default.
• W2990599467 cites W2109907166 @default.
• W2990599467 cites W2110599341 @default.
• W2990599467 cites W2124756133 @default.
• W2990599467 cites W2134202053 @default.
• W2990599467 cites W2134893281 @default.
• W2990599467 cites W2135059404 @default.
• W2990599467 cites W2136154089 @default.
• W2990599467 cites W2138855865 @default.
• W2990599467 cites W2152239989 @default.
• W2990599467 cites W2162126890 @default.
• W2990599467 cites W2167557255 @default.
• W2990599467 cites W2337198543 @default.
• W2990599467 cites W2346277053 @default.
• W2990599467 cites W2401470254 @default.
• W2990599467 cites W2528000615 @default.
• W2990599467 cites W2564527805 @default.
• W2990599467 cites W2806605536 @default.
• W2990599467 cites W2809454321 @default.
• W2990599467 cites W2980920683 @default.
• W2990599467 cites W4211206238 @default.
• W2990599467 doi "https://doi.org/10.12659/msm.917925" @default.
• W2990599467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6900925" @default.
• W2990599467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31776323" @default.
• W2990599467 hasPublicationYear "2019" @default.
• W2990599467 type Work @default.
• W2990599467 sameAs 2990599467 @default.
• W2990599467 citedByCount "1" @default.
• W2990599467 countsByYear W29905994672021 @default.
• W2990599467 crossrefType "journal-article" @default.
• W2990599467 hasAuthorship W2990599467A5017269103 @default.
• W2990599467 hasAuthorship W2990599467A5029984685 @default.
• W2990599467 hasAuthorship W2990599467A5032529955 @default.
• W2990599467 hasAuthorship W2990599467A5073036869 @default.
• W2990599467 hasBestOaLocation W29905994672 @default.
• W2990599467 hasConcept C104317684 @default.
• W2990599467 hasConcept C105580179 @default.
• W2990599467 hasConcept C14036430 @default.
• W2990599467 hasConcept C145059251 @default.
• W2990599467 hasConcept C150194340 @default.
• W2990599467 hasConcept C48023723 @default.
• W2990599467 hasConcept C54355233 @default.
• W2990599467 hasConcept C60644358 @default.
• W2990599467 hasConcept C62478195 @default.
• W2990599467 hasConcept C70721500 @default.
• W2990599467 hasConcept C86803240 @default.
• W2990599467 hasConceptScore W2990599467C104317684 @default.
• W2990599467 hasConceptScore W2990599467C105580179 @default.
• W2990599467 hasConceptScore W2990599467C14036430 @default.
• W2990599467 hasConceptScore W2990599467C145059251 @default.
• W2990599467 hasConceptScore W2990599467C150194340 @default.
• W2990599467 hasConceptScore W2990599467C48023723 @default.
• W2990599467 hasConceptScore W2990599467C54355233 @default.
• W2990599467 hasConceptScore W2990599467C60644358 @default.
• W2990599467 hasConceptScore W2990599467C62478195 @default.
• W2990599467 hasConceptScore W2990599467C70721500 @default.
• W2990599467 hasConceptScore W2990599467C86803240 @default.
• W2990599467 hasLocation W29905994671 @default.
• W2990599467 hasLocation W29905994672 @default.
• W2990599467 hasLocation W29905994673 @default.
• W2990599467 hasLocation W29905994674 @default.
• W2990599467 hasOpenAccess W2990599467 @default.
• W2990599467 hasPrimaryLocation W29905994671 @default.
• W2990599467 hasRelatedWork W1974846613 @default.
• W2990599467 hasRelatedWork W1987603245 @default.
• W2990599467 hasRelatedWork W2005531722 @default.
• W2990599467 hasRelatedWork W2006583056 @default.
• W2990599467 hasRelatedWork W2009966535 @default.
• W2990599467 hasRelatedWork W2052477901 @default.
• W2990599467 hasRelatedWork W2358052149 @default.
• W2990599467 hasRelatedWork W2381294515 @default.
• W2990599467 hasRelatedWork W2381595426 @default.
• W2990599467 hasRelatedWork W2754703032 @default.
• W2990599467 hasVolume "25" @default.
• W2990599467 isParatext "false" @default.
• W2990599467 isRetracted "false" @default.

• next