FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990634507> ?p ?o ?g. }

• W2990634507 endingPage "1886" @default.
• W2990634507 startingPage "1886" @default.
• W2990634507 abstract "The human genome is organized into topologically associating domains (TADs), which represent contiguous regions with a higher frequency of intra-interactions as opposed to inter-interactions. TADs contribute to gene expression regulation by restricting the interactions between their regulatory elements, and TAD disruption has been associated with cancer. Here, we provide a proof of principle that mutations within TADs can be used to predict the survival of cancer patients. Specifically, we constructed a set of 1467 consensus TADs representing the three-dimensional organization of the human genome and used Cox regression analysis to identify a total of 35 prognostic TADs in different cancer types. Interestingly, only 46% of the 35 prognostic TADs comprised genes with known clinical relevance. Moreover, in the vast majority of such cases, the prognostic value of the TAD was not directly related to the presence/absence of mutations in the gene(s), emphasizing the importance of regulatory mutations. In addition, we found that 34% of the prognostic TADs show strong structural perturbations in the cancer genome, consistent with the widespread, global epigenetic dysregulation often observed in cancer patients. In summary, this study elucidates the mechanisms through which non-coding variants may influence cancer progression and opens new avenues for personalized medicine." @default.
• W2990634507 created "2019-12-05" @default.
• W2990634507 creator A5009398662 @default.
• W2990634507 creator A5014489598 @default.
• W2990634507 creator A5053257775 @default.
• W2990634507 creator A5085497974 @default.
• W2990634507 date "2019-11-27" @default.
• W2990634507 modified "2023-10-14" @default.
• W2990634507 title "Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome" @default.
• W2990634507 cites W1544419537 @default.
• W2990634507 cites W1859117663 @default.
• W2990634507 cites W1924378360 @default.
• W2990634507 cites W1963740134 @default.
• W2990634507 cites W1973062929 @default.
• W2990634507 cites W1978329681 @default.
• W2990634507 cites W2030710966 @default.
• W2990634507 cites W2034979835 @default.
• W2990634507 cites W2044702943 @default.
• W2990634507 cites W2046666786 @default.
• W2990634507 cites W2068065958 @default.
• W2990634507 cites W2070021921 @default.
• W2990634507 cites W2084139018 @default.
• W2990634507 cites W2090037139 @default.
• W2990634507 cites W2097360283 @default.
• W2990634507 cites W2104163599 @default.
• W2990634507 cites W2118527670 @default.
• W2990634507 cites W2133465414 @default.
• W2990634507 cites W2137297899 @default.
• W2990634507 cites W2140292293 @default.
• W2990634507 cites W2149199519 @default.
• W2990634507 cites W2158217645 @default.
• W2990634507 cites W2158485828 @default.
• W2990634507 cites W2158789637 @default.
• W2990634507 cites W2161212572 @default.
• W2990634507 cites W2179438025 @default.
• W2990634507 cites W2222531233 @default.
• W2990634507 cites W2259938310 @default.
• W2990634507 cites W2275678839 @default.
• W2990634507 cites W2303393194 @default.
• W2990634507 cites W2324391617 @default.
• W2990634507 cites W2324665822 @default.
• W2990634507 cites W2344228791 @default.
• W2990634507 cites W23842477 @default.
• W2990634507 cites W2413370544 @default.
• W2990634507 cites W2416744721 @default.
• W2990634507 cites W2466523221 @default.
• W2990634507 cites W2528263447 @default.
• W2990634507 cites W2557097554 @default.
• W2990634507 cites W2561117921 @default.
• W2990634507 cites W2596601694 @default.
• W2990634507 cites W2597925416 @default.
• W2990634507 cites W2604022024 @default.
• W2990634507 cites W2765468373 @default.
• W2990634507 cites W2792469977 @default.
• W2990634507 cites W2800772973 @default.
• W2990634507 cites W2802911736 @default.
• W2990634507 cites W2949421579 @default.
• W2990634507 cites W2949808761 @default.
• W2990634507 cites W2966027467 @default.
• W2990634507 cites W4294541781 @default.
• W2990634507 doi "https://doi.org/10.3390/cancers11121886" @default.
• W2990634507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6966451" @default.
• W2990634507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31783642" @default.
• W2990634507 hasPublicationYear "2019" @default.
• W2990634507 type Work @default.
• W2990634507 sameAs 2990634507 @default.
• W2990634507 citedByCount "13" @default.
• W2990634507 countsByYear W29906345072020 @default.
• W2990634507 countsByYear W29906345072021 @default.
• W2990634507 countsByYear W29906345072023 @default.
• W2990634507 crossrefType "journal-article" @default.
• W2990634507 hasAuthorship W2990634507A5009398662 @default.
• W2990634507 hasAuthorship W2990634507A5014489598 @default.
• W2990634507 hasAuthorship W2990634507A5053257775 @default.
• W2990634507 hasAuthorship W2990634507A5085497974 @default.
• W2990634507 hasBestOaLocation W29906345071 @default.
• W2990634507 hasConcept C104317684 @default.
• W2990634507 hasConcept C121608353 @default.
• W2990634507 hasConcept C141231307 @default.
• W2990634507 hasConcept C197077220 @default.
• W2990634507 hasConcept C41091548 @default.
• W2990634507 hasConcept C54355233 @default.
• W2990634507 hasConcept C60644358 @default.
• W2990634507 hasConcept C70721500 @default.
• W2990634507 hasConcept C86803240 @default.
• W2990634507 hasConceptScore W2990634507C104317684 @default.
• W2990634507 hasConceptScore W2990634507C121608353 @default.
• W2990634507 hasConceptScore W2990634507C141231307 @default.
• W2990634507 hasConceptScore W2990634507C197077220 @default.
• W2990634507 hasConceptScore W2990634507C41091548 @default.
• W2990634507 hasConceptScore W2990634507C54355233 @default.
• W2990634507 hasConceptScore W2990634507C60644358 @default.
• W2990634507 hasConceptScore W2990634507C70721500 @default.
• W2990634507 hasConceptScore W2990634507C86803240 @default.
• W2990634507 hasIssue "12" @default.
• W2990634507 hasLocation W29906345071 @default.
• W2990634507 hasLocation W29906345072 @default.
• W2990634507 hasLocation W29906345073 @default.

• next