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- W2990641098 abstract "Two ruthenium complexes containing a new phenanthroline‐based ligand pai (pai = 2‐(5‐(1, 10‐ phenanthroline))‐1H‐acenaphtho[1′,2′:4,5]imidazole) were synthesized and characterized. Two ruthenium complexes were found to cleave DNA under irradiation, interact with CT‐DNA by intercalation. Furthermore, DNA topoisomerase inhibition experiments indicated that complex 2 exhibited higher topoisomerase I inhibition activity (IC 50 = 10 μM) than complex 1 (IC 50 = 40 μM). Molecular modeling studies revealed that complex 2 stabilized Top1cc complex via π‐π interaction and the formation of hydrogen bond. The cytotoxicity of complexes 1 and 2 against Eca‐109 and A549 cells was also evaluate by MTT method, indicating that complex 2 exhibited good anticancer activity against Eca‐109 cells (IC 50 = 17.23 ± 0.22 μM), but two ruthenium complexes displayed weak anticancer activity against A549 cells." @default.
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- W2990641098 date "2019-12-01" @default.
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- W2990641098 title "Topo I inhibition, DNA photocleavage, Molecular docking and cytotoxicities of two new phenanthroline‐based ruthenium complexes" @default.
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- W2990641098 doi "https://doi.org/10.1002/aoc.5312" @default.
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