FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990717241> ?p ?o ?g. }

• W2990717241 endingPage "421" @default.
• W2990717241 startingPage "415" @default.
• W2990717241 abstract "Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified. Here, we provide the first evidence that membrane repair dependent on endosomal sorting complexes required for transport (ESCRT)-III negatively regulates ferroptotic cancer cell death. The accumulation of ESCRT-III subunits (e.g., CHMP5 and CHMP6) in the plasma membrane are increased by classical ferroptosis activators (e.g., erastin and RSL3), which relies on endoplasmic reticulum stress and calcium influx. Importantly, the knockdown of CHMP5 or CHMP6 by RNAi sensitizes human cancer cells (e.g., PANC1 and HepG2) to lipid peroxidation-mediated ferroptosis in vitro and in vivo. These findings suggest that ESCRT-III confers resistance to ferroptotic cell death, allowing cell survival under stress conditions." @default.
• W2990717241 created "2019-12-05" @default.
• W2990717241 creator A5018853571 @default.
• W2990717241 creator A5037212511 @default.
• W2990717241 creator A5041439110 @default.
• W2990717241 creator A5055468442 @default.
• W2990717241 creator A5091664811 @default.
• W2990717241 date "2020-02-01" @default.
• W2990717241 modified "2023-10-16" @default.
• W2990717241 title "ESCRT-III–dependent membrane repair blocks ferroptosis" @default.
• W2990717241 cites W1545874413 @default.
• W2990717241 cites W1821729734 @default.
• W2990717241 cites W1871390418 @default.
• W2990717241 cites W1975617209 @default.
• W2990717241 cites W1997183854 @default.
• W2990717241 cites W2002490399 @default.
• W2990717241 cites W2007794772 @default.
• W2990717241 cites W2017649638 @default.
• W2990717241 cites W2035898183 @default.
• W2990717241 cites W2045171661 @default.
• W2990717241 cites W2057632732 @default.
• W2990717241 cites W2085224193 @default.
• W2990717241 cites W2099792161 @default.
• W2990717241 cites W2110642055 @default.
• W2990717241 cites W2114242405 @default.
• W2990717241 cites W2138138539 @default.
• W2990717241 cites W2151651301 @default.
• W2990717241 cites W2163005196 @default.
• W2990717241 cites W2163294546 @default.
• W2990717241 cites W2226584831 @default.
• W2990717241 cites W2265062179 @default.
• W2990717241 cites W2285203836 @default.
• W2990717241 cites W2305753128 @default.
• W2990717241 cites W2414659015 @default.
• W2990717241 cites W2582111083 @default.
• W2990717241 cites W2604229956 @default.
• W2990717241 cites W2736008368 @default.
• W2990717241 cites W2745520112 @default.
• W2990717241 cites W2747049873 @default.
• W2990717241 cites W2761645877 @default.
• W2990717241 cites W2762087180 @default.
• W2990717241 cites W2766031263 @default.
• W2990717241 cites W2781645302 @default.
• W2990717241 cites W2788640168 @default.
• W2990717241 cites W2794703348 @default.
• W2990717241 cites W2808965517 @default.
• W2990717241 cites W2885642918 @default.
• W2990717241 cites W2900507152 @default.
• W2990717241 cites W2904913900 @default.
• W2990717241 cites W2912822929 @default.
• W2990717241 cites W2913973491 @default.
• W2990717241 cites W2916144846 @default.
• W2990717241 cites W2921575300 @default.
• W2990717241 cites W2935369648 @default.
• W2990717241 cites W2964024721 @default.
• W2990717241 cites W2973378552 @default.
• W2990717241 doi "https://doi.org/10.1016/j.bbrc.2019.11.110" @default.
• W2990717241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6957708" @default.
• W2990717241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31761326" @default.
• W2990717241 hasPublicationYear "2020" @default.
• W2990717241 type Work @default.
• W2990717241 sameAs 2990717241 @default.
• W2990717241 citedByCount "112" @default.
• W2990717241 countsByYear W29907172412020 @default.
• W2990717241 countsByYear W29907172412021 @default.
• W2990717241 countsByYear W29907172412022 @default.
• W2990717241 countsByYear W29907172412023 @default.
• W2990717241 crossrefType "journal-article" @default.
• W2990717241 hasAuthorship W2990717241A5018853571 @default.
• W2990717241 hasAuthorship W2990717241A5037212511 @default.
• W2990717241 hasAuthorship W2990717241A5041439110 @default.
• W2990717241 hasAuthorship W2990717241A5055468442 @default.
• W2990717241 hasAuthorship W2990717241A5091664811 @default.
• W2990717241 hasBestOaLocation W29907172412 @default.
• W2990717241 hasConcept C102747710 @default.
• W2990717241 hasConcept C121608353 @default.
• W2990717241 hasConcept C143876685 @default.
• W2990717241 hasConcept C1491633281 @default.
• W2990717241 hasConcept C158617107 @default.
• W2990717241 hasConcept C173396325 @default.
• W2990717241 hasConcept C185592680 @default.
• W2990717241 hasConcept C190283241 @default.
• W2990717241 hasConcept C2776151105 @default.
• W2990717241 hasConcept C2780829032 @default.
• W2990717241 hasConcept C31573885 @default.
• W2990717241 hasConcept C54355233 @default.
• W2990717241 hasConcept C55493867 @default.
• W2990717241 hasConcept C79879829 @default.
• W2990717241 hasConcept C86803240 @default.
• W2990717241 hasConcept C95444343 @default.
• W2990717241 hasConcept C96232424 @default.
• W2990717241 hasConceptScore W2990717241C102747710 @default.
• W2990717241 hasConceptScore W2990717241C121608353 @default.
• W2990717241 hasConceptScore W2990717241C143876685 @default.
• W2990717241 hasConceptScore W2990717241C1491633281 @default.
• W2990717241 hasConceptScore W2990717241C158617107 @default.
• W2990717241 hasConceptScore W2990717241C173396325 @default.
• W2990717241 hasConceptScore W2990717241C185592680 @default.

• next