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- W2990734695 abstract "Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD) and Schizophrenia mainly target disease symptoms. Thus, there is an urgent need to develop novel therapeutics that can delay, halt or reverse disease progression. AD, HD, PD and schizophrenia are characterized by elevated oxidative and nitrosative stress, which play a central role in pathogenesis. Clinical trials utilizing antioxidants to counter disease progression have largely been unsuccessful. Most antioxidants are relatively non-specific and do not adequately target neuroprotective pathways. Accordingly, a search for agents that restore redox balance as well as halt or reverse neuronal loss is underway. The small molecules, cysteamine, the decarboxylated derivative of the amino acid cysteine, and cystamine, the oxidized form of cysteamine respectively, mitigate oxidative stress and inflammation and upregulate neuroprotective pathways involving brain-derived neurotrophic factor (BDNF) and Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling. Cysteamine can traverse the blood brain barrier, a desirable characteristic of drugs targeting neurodegeneration. This review addresses recent developments in the use of these aminothiols to counter neurodegeneration and neuropsychiatric deficits." @default.
- W2990734695 created "2019-12-05" @default.
- W2990734695 creator A5006367625 @default.
- W2990734695 creator A5020208893 @default.
- W2990734695 date "2019-12-12" @default.
- W2990734695 modified "2023-10-01" @default.
- W2990734695 title "Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases" @default.
- W2990734695 cites W10027490 @default.
- W2990734695 cites W141547775 @default.
- W2990734695 cites W147769263 @default.
- W2990734695 cites W1500860041 @default.
- W2990734695 cites W1607485899 @default.
- W2990734695 cites W1692886302 @default.
- W2990734695 cites W1892455234 @default.
- W2990734695 cites W1963564729 @default.
- W2990734695 cites W1965247936 @default.
- W2990734695 cites W1966735516 @default.
- W2990734695 cites W1971714082 @default.
- W2990734695 cites W1971811680 @default.
- W2990734695 cites W1973454873 @default.
- W2990734695 cites W1974300727 @default.
- W2990734695 cites W1975560931 @default.
- W2990734695 cites W1978745534 @default.
- W2990734695 cites W1978961333 @default.
- W2990734695 cites W1982598270 @default.
- W2990734695 cites W1988057087 @default.
- W2990734695 cites W1997288864 @default.
- W2990734695 cites W2001933020 @default.
- W2990734695 cites W2003428612 @default.
- W2990734695 cites W2011658706 @default.
- W2990734695 cites W2012608478 @default.
- W2990734695 cites W2012724283 @default.
- W2990734695 cites W2016642002 @default.
- W2990734695 cites W2024430507 @default.
- W2990734695 cites W2029112933 @default.
- W2990734695 cites W2029870086 @default.
- W2990734695 cites W2030776967 @default.
- W2990734695 cites W2031540283 @default.
- W2990734695 cites W2033676261 @default.
- W2990734695 cites W2035574613 @default.
- W2990734695 cites W2039315720 @default.
- W2990734695 cites W2044374226 @default.
- W2990734695 cites W2047517357 @default.
- W2990734695 cites W2050147439 @default.
- W2990734695 cites W2051775286 @default.
- W2990734695 cites W2051788484 @default.
- W2990734695 cites W2054749434 @default.
- W2990734695 cites W2057892557 @default.
- W2990734695 cites W2059465632 @default.
- W2990734695 cites W2060750433 @default.
- W2990734695 cites W2062572062 @default.
- W2990734695 cites W2062691596 @default.
- W2990734695 cites W2066863701 @default.
- W2990734695 cites W2070055784 @default.
- W2990734695 cites W2072143544 @default.
- W2990734695 cites W2074782316 @default.
- W2990734695 cites W2079313641 @default.
- W2990734695 cites W2079813087 @default.
- W2990734695 cites W2080147271 @default.
- W2990734695 cites W2082119173 @default.
- W2990734695 cites W2085014212 @default.
- W2990734695 cites W2091204354 @default.
- W2990734695 cites W2096386031 @default.
- W2990734695 cites W2096409578 @default.
- W2990734695 cites W2107007950 @default.
- W2990734695 cites W2107768418 @default.
- W2990734695 cites W2121075670 @default.
- W2990734695 cites W2122389485 @default.
- W2990734695 cites W2126850843 @default.
- W2990734695 cites W2139769475 @default.
- W2990734695 cites W2141674087 @default.
- W2990734695 cites W2143912446 @default.
- W2990734695 cites W2147285875 @default.
- W2990734695 cites W2148589294 @default.
- W2990734695 cites W2152668149 @default.
- W2990734695 cites W2156788921 @default.
- W2990734695 cites W2157940538 @default.
- W2990734695 cites W2160039765 @default.
- W2990734695 cites W2163628857 @default.
- W2990734695 cites W2163928791 @default.
- W2990734695 cites W2169287384 @default.
- W2990734695 cites W2171032841 @default.
- W2990734695 cites W2171990628 @default.
- W2990734695 cites W2177909750 @default.
- W2990734695 cites W2185348657 @default.
- W2990734695 cites W2245206135 @default.
- W2990734695 cites W2300791493 @default.
- W2990734695 cites W2403273387 @default.
- W2990734695 cites W2472670232 @default.
- W2990734695 cites W2474023059 @default.
- W2990734695 cites W2491404716 @default.
- W2990734695 cites W2508480470 @default.
- W2990734695 cites W2556818673 @default.
- W2990734695 cites W2557282926 @default.
- W2990734695 cites W2564130689 @default.
- W2990734695 cites W2565280039 @default.
- W2990734695 cites W2603021068 @default.
- W2990734695 cites W2605122995 @default.
- W2990734695 cites W2745482791 @default.
- W2990734695 cites W2772997542 @default.